MdtEF-TolC

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Accession ARO:3000788
Synonym(s)YhiUV-TolC
CARD Short NameMdtEF-TolC
DefinitionMdtEF-TolC is a multidrug efflux complex in Gram-negative bacteria, including E. coli. MdtE is the membrane fusion protein, MdtF is the inner membrane transporter, while TolC is the outer membrane channel.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpenicillin beta-lactam, fluoroquinolone antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification11 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic cloxacillin [Antibiotic]
+ confers_resistance_to_antibiotic oxacillin [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic norfloxacin [Antibiotic]
Sub-Term(s)
8 ontology terms | Show
+ mdtE part_of
+ mdtF part_of
+ TolC part_of
+ CRP regulates
+ evgSA regulates
+ gadX regulates
+ H-NS regulates
+ gadW regulates
Publications

Nishino K and Yamaguchi A. 2004. J Bacteriol 186(5): 1423-1429. Role of histone-like protein H-NS in multidrug resistance of Escherichia coli. (PMID 14973023)
Resistomes

Prevalence of MdtEF-TolC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
No prevalence data


Detection Models

Model Name: MdtEF-TolC

Model Description: MdtEF-TolC is a multidrug efflux complex in Gram-negative bacteria, including E. coli. MdtE is the membrane fusion protein, MdtF is the inner membrane transporter, while TolC is the outer membrane channel.

evgAmdtFCRPgadXevgSH-NSTolCmdtEgadW
Curator Acknowledgements
Curator Description Most Recent Edit