| Accession | ARO:3000832 |
| CARD Short Name | evgA |
| Definition | EvgA, when phosphorylated, is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner, it can be phosphorylated in the absence of EvgS when overexpressed. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump, major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | tetracycline antibiotic, penam, fluoroquinolone antibiotic, macrolide antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
| Resistomes with Perfect Matches | Escherichia colig+p+wgs+gi, Shigella boydiig+wgs+gi, Shigella dysenteriaeg+wgs+gi, Shigella flexnerig+wgs+gi, Shigella sonneig+wgs |
| Resistomes with Sequence Variants | Escherichia colig+p+wgs+gi, Klebsiella pneumoniaewgs, Shigella boydiig+wgs+gi, Shigella dysenteriaeg+wgs+gi, Shigella flexnerig+wgs+gi, Shigella sonneig+wgs+gi |
| Classification | 21 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + beta-lactam antibiotic + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + tetracycline antibiotic [Drug Class] + penam [Drug Class] + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + norfloxacin [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + oxacillin [Antibiotic] + tetracycline [Antibiotic] + cloxacillin [Antibiotic] + erythromycin [Antibiotic] + MdtEF-TolC + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + EmrKY-TolC |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Hirakawa H, et al. 2003. J. Antimicrob. Chemother. 52(4):576-82 Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. (PMID 12951338) |
Prevalence of evgA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Escherichia coli | 67.34% | 0.12% | 60.9% | 67.18% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% |
| Shigella boydii | 100% | 0% | 91.11% | 100% |
| Shigella dysenteriae | 92.86% | 0% | 70% | 25% |
| Shigella flexneri | 100% | 0% | 79.97% | 40.48% |
| Shigella sonnei | 100% | 0% | 94.74% | 33.33% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 390