macrolide antibiotic [Drug Class]

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Accession ARO:0000000
DefinitionMacrolides are a group of drugs (typically antibiotics) that have a large macrocyclic lactone ring of 12-16 carbons to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. Macrolides bind to the 50S-subunit of bacterial ribosomes, inhibiting the synthesis of vital proteins.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
58 ontology terms | Show
+ erythromycin [Antibiotic]
+ roxithromycin [Antibiotic]
+ clarithromycin [Antibiotic]
+ telithromycin [Antibiotic]
+ tylosin [Antibiotic]
+ spiramycin [Antibiotic]
+ azithromycin [Antibiotic]
+ dirithromycin [Antibiotic]
+ oleandomycin [Antibiotic]
+ josamycin [Antibiotic]
+ chalcomycin [Antibiotic]
+ midecamycin [Antibiotic]
+ mycinamicin [Antibiotic]
+ megalomycin [Antibiotic]
+ narbomycin [Antibiotic]
+ kitasamycin [Antibiotic]
+ carbomycin [Antibiotic]
+ rosaramicin [Antibiotic]
+ niddamycin [Antibiotic]
+ methymycin [Antibiotic]
+ pikromycin [Antibiotic]
+ rokitamycin [Antibiotic]
+ Solithromycin [Antibiotic]
+ cethromycin [Antibiotic]
+ carrimycin [Antibiotic]
+ tilmicosin [Antibiotic]
+ Mycaminosyltylonolide [Antibiotic]
+ tulathromycin [Antibiotic]
+ gamithromycin [Antibiotic]
+ tildipirosin [Antibiotic]
+ Marinomycin
+ Tartrolon
+ aplasmomycin [Antibiotic]
+ boromycin [Antibiotic]
+ Azalomycin F [Antibiotic]
+ tylvalosin [Antibiotic]
+ MexCD-OprJ confers_resistance_to_drug_class
+ MexXY-OprM confers_resistance_to_drug_class
+ lmrP confers_resistance_to_drug_class
+ mef confers_resistance_to_drug_class
+ MexAB-OprM confers_resistance_to_drug_class
+ SmeDEF confers_resistance_to_drug_class
+ AdeIJK confers_resistance_to_drug_class
+ LpeAB confers_resistance_to_drug_class
+ 23S rRNA with mutation conferring resistance to macrolide antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ macrolide esterase [AMR Gene Family] confers_resistance_to_drug_class
+ ole glycosyltransferase [AMR Gene Family] confers_resistance_to_drug_class
+ gimA family macrolide glycosyltransferase [AMR Gene Family] confers_resistance_to_drug_class
+ mgt macrolide glycotransferase [AMR Gene Family] confers_resistance_to_drug_class
+ macrolide phosphotransferase (MPH) [AMR Gene Family] confers_resistance_to_drug_class
+ Erm 23S ribosomal RNA methyltransferase [AMR Gene Family] confers_resistance_to_drug_class
+ non-erm 23S ribosomal RNA methyltransferase (G748) [AMR Gene Family] confers_resistance_to_drug_class
+ 23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ 50S rRNA with mutation conferring resistance to macrolide antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ mef(D) confers_resistance_to_drug_class
+ mreA confers_resistance_to_drug_class
+ msr-type ABC-F protein [AMR Gene Family] confers_resistance_to_drug_class
+ 50S ribosomal subunit targeted_by
Publications

Zhanel GG, et al. 2001. Drugs 61(4): 443-498. Review of macrolides and ketolides: focus on respiratory tract infections. (PMID 11324679)

Jain R and Danziger LH. 2004. Curr Pharm Des 10(25): 3045-3053. The macrolide antibiotics: a pharmacokinetic and pharmacodynamic overview. (PMID 15544496)

Yoshioka D, et al. 2016. Antimicrob. Agents Chemother. : The efficacy of β-lactam plus macrolide combination therapy in a mouse model of lethal pneumococcal pneumonia. (PMID 27480866)