mef

Accession ARO:3000747
DefinitionMef efflux pumps are MFS-type transporters that confer macrolide resistance in Streptococcus pneumoniae.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, phenicol antibiotic, oxazolidinone antibiotic, glycylcycline, benzalkonium chloride, rifamycin antibiotic, nitroimidazole antibiotic, antibacterial free fatty acids, peptide antibiotic, rhodamine, bicyclomycin, cephalosporin, lincosamide antibiotic, nucleoside antibiotic, fosfomycin, diaminopyrimidine antibiotic, acridine dye, fluoroquinolone antibiotic, penam, macrolide antibiotic, isoniazid
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Sub-Term(s)
4 ontology terms | Show
Publications

Ambrose KD, et al. 2005. Antimicrob Agents Chemother 49(10): 4203-4209. Macrolide efflux in Streptococcus pneumoniae is mediated by a dual efflux pump (mel and mef) and is erythromycin inducible. (PMID 16189099)