Accession ARO:3000747
DefinitionMef efflux pumps are MFS-type transporters that confer macrolide resistance in Streptococcus pneumoniae.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification6 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
7 ontology terms | Show

Ambrose KD, et al. 2005. Antimicrob Agents Chemother 49(10): 4203-4209. Macrolide efflux in Streptococcus pneumoniae is mediated by a dual efflux pump (mel and mef) and is erythromycin inducible. (PMID 16189099)