Mef(En2)

Accession ARO:3004659
CARD Short NameMef(En2)
DefinitionNBU2-encoded resistance gene. An MefE homolog in Bacteroides species. Macrolide efflux MFS transporter.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classmacrolide antibiotic, lincosamide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Sequence VariantsBacteroides caccaewgs, Bacteroides fragilisg+wgs, Bacteroides ovatuswgs, Bacteroides thetaiotaomicrong+wgs, Parabacteroides distasoniswgs, Phocaeicola doreig+wgs, Phocaeicola massiliensiswgs, Phocaeicola vulgatusg+wgs, Riemerella anatipestiferg+wgs
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ mef
+ confers_resistance_to_antibiotic lincomycin [Antibiotic]
Publications

Wang J, et al. 2000. J. Bacteriol. 182(12):3559-71 Characterization of a Bacteroides mobilizable transposon, NBU2, which carries a functional lincomycin resistance gene. (PMID 10852890)

Resistomes

Prevalence of Mef(En2) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Bacteroides caccae0%0%21.25%0%
Bacteroides fragilis26.92%0%15.12%0%
Bacteroides ovatus0%0%7.6%0%
Bacteroides thetaiotaomicron21.43%0%11.54%0%
Parabacteroides distasonis0%0%6.07%0%
Phocaeicola dorei18.18%0%45.83%0%
Phocaeicola massiliensis0%0%11.54%0%
Phocaeicola vulgatus16.67%0%21.45%0%
Riemerella anatipestifer5.56%0%2.08%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 700


>gb|AAF74725.1|-|Mef(En2) [Bacteroides fragilis]
MNHWKSTLAVIGIGQLISILTSTIVGFSIIFWISNEFKSPTALSLAILAGFLPQFVLGLFAGVYVDRWNRKKTMFYSDLFIAFCTLCLFI
VITKGYKDLSFFYLLTACRSIGSTFHAPALQASIPLLVPKHHLVRVSGLYHSIQSFSEVIAPVVGASLVVWLPIQYILLIDVIGAVAACL
TLLCVQIPSLQKTKVLPDFKKELTEWLHTLRRTMGILPLFVCFTLVTFVLMPVFTLFPFMTLLHFNGNILQMGVVEMGWGSGALLGGLVL
ACKALKSKQTLVMHTAYVILGLYLISASYLPSSAFIGFVCLTFTGGIAYSIYHALFIAIIQQNLASDMLGRTFSLIFSLSTFPSMLGIVA
SGYWVEAWGITSVFMISGWVIFLIGVGANFISSIKQLDNYA


>gb|AF251288.1|-|795-2000|Mef(En2) [Bacteroides fragilis]
ATGAATCATTGGAAATCAACTTTGGCCGTGATAGGAATAGGCCAACTCATATCTATTTTAACAAGTACGATTGTTGGCTTCTCCATTATT
TTTTGGATTAGCAACGAATTTAAATCCCCGACAGCTTTATCTCTGGCTATTTTAGCTGGATTTTTACCACAATTTGTATTAGGCTTGTTT
GCCGGGGTCTATGTTGACAGATGGAATCGAAAGAAAACGATGTTTTATTCGGACTTGTTCATCGCGTTCTGTACCCTATGTCTTTTTATT
GTGATAACCAAGGGTTATAAAGACCTTTCTTTTTTTTATCTATTGACTGCTTGTCGTTCAATAGGCAGTACGTTTCATGCACCTGCTTTA
CAGGCAAGCATCCCTCTACTGGTTCCCAAGCACCATCTTGTCAGGGTATCAGGTTTGTACCATTCCATTCAATCCTTCAGTGAGGTGATA
GCTCCCGTTGTAGGGGCAAGCCTCGTTGTTTGGCTTCCCATACAGTATATTCTGCTCATAGATGTGATCGGAGCTGTTGCTGCTTGTCTG
ACCTTACTTTGTGTCCAGATTCCTTCTCTTCAAAAAACGAAAGTTCTTCCAGATTTCAAAAAAGAACTGACGGAATGGTTGCATACCTTG
CGGCGTACAATGGGCATTTTGCCTTTATTCGTATGCTTTACGCTGGTGACTTTTGTCCTTATGCCTGTTTTTACGTTATTTCCTTTTATG
ACGCTTCTGCATTTCAACGGAAACATTTTGCAAATGGGAGTTGTGGAAATGGGTTGGGGCTCAGGGGCATTGTTGGGCGGTTTAGTACTT
GCCTGTAAGGCTTTGAAAAGCAAGCAAACATTAGTGATGCATACGGCTTATGTGATATTGGGATTGTATCTGATTAGCGCCAGTTATTTA
CCATCAAGCGCATTTATAGGTTTTGTTTGCCTAACATTTACAGGAGGCATAGCCTATTCCATTTACCATGCGCTTTTCATCGCTATTATT
CAGCAGAACTTGGCTTCGGACATGCTTGGACGGACTTTTTCTCTCATCTTTAGTTTGAGTACCTTTCCATCAATGCTGGGTATCGTAGCT
TCAGGATATTGGGTGGAAGCATGGGGTATCACATCCGTCTTTATGATCAGCGGATGGGTTATCTTTCTGATTGGAGTGGGTGCAAATTTT
ATTTCTTCAATCAAGCAGTTGGATAATTACGCATAG