lincomycin [Antibiotic]

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Accession ARO:0000046
Synonym(s)Cillimycin Lincolnensin Lincomycinum Lincomycine Lincomicina Jiemycin Lincolcina Lincocin Lincomycin A Epilincomycin
DefinitionLincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction.
Drug Classlincosamide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ lincosamide antibiotic [Drug Class]
32 ontology terms | Show
+ antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by_antibiotic
+ ErmC confers_resistance_to_antibiotic
+ ErmC' confers_resistance_to_antibiotic
+ ErmE confers_resistance_to_antibiotic
+ ErmA confers_resistance_to_antibiotic
+ ErmB confers_resistance_to_antibiotic
+ Erm(37) confers_resistance_to_antibiotic
+ ErmD confers_resistance_to_antibiotic
+ ErmF confers_resistance_to_antibiotic
+ ErmG confers_resistance_to_antibiotic
+ ErmI confers_resistance_to_antibiotic
+ ErmN confers_resistance_to_antibiotic
+ ErmQ confers_resistance_to_antibiotic
+ ErmR confers_resistance_to_antibiotic
+ ErmT confers_resistance_to_antibiotic
+ ErmX confers_resistance_to_antibiotic
+ Erm(31) confers_resistance_to_antibiotic
+ Erm(33) confers_resistance_to_antibiotic
+ Erm(34) confers_resistance_to_antibiotic
+ Erm(38) confers_resistance_to_antibiotic
+ Erm(39) confers_resistance_to_antibiotic
+ Erm(41) confers_resistance_to_antibiotic
+ Erm(35) confers_resistance_to_antibiotic
+ Erm(36) confers_resistance_to_antibiotic
+ cipA confers_resistance_to_antibiotic
+ cfrA confers_resistance_to_antibiotic
+ clbA confers_resistance_to_antibiotic
+ clbB confers_resistance_to_antibiotic
+ clbC confers_resistance_to_antibiotic
+ lnuG confers_resistance_to_antibiotic
+ vmlR confers_resistance_to_antibiotic
+ mdtM confers_resistance_to_antibiotic

Roberts MC, et al. 1999. Antimicrob Agents Chemother 43(12): 2823-2830. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. (PMID 10582867)

Doktor SZ, et al. 2004. Diagn Microbiol Infect Dis 49(1): 47-52. Epidemiology of macrolide and/or lincosamide resistant Streptococcus pneumoniae clinical isolates with ribosomal mutations. (PMID 15135500)