lincomycin [Antibiotic]

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Accession ARO:0000046
Synonym(s)Cillimycin Epilincomycin Jiemycin Lincocin Lincolcina Lincolnensin Lincomicina Lincomycin A Lincomycine Lincomycinum
DefinitionLincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. It binds to the 23s portion of the 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction.
Drug Classlincosamide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ lincosamide antibiotic [Drug Class]
Sub-Term(s)
61 ontology terms | Show
+ antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by_antibiotic
+ ErmC confers_resistance_to_antibiotic
+ ErmE confers_resistance_to_antibiotic
+ ErmA confers_resistance_to_antibiotic
+ ErmB confers_resistance_to_antibiotic
+ Erm(37) confers_resistance_to_antibiotic
+ ErmD confers_resistance_to_antibiotic
+ ErmF confers_resistance_to_antibiotic
+ ErmG confers_resistance_to_antibiotic
+ ErmN confers_resistance_to_antibiotic
+ ErmQ confers_resistance_to_antibiotic
+ ErmR confers_resistance_to_antibiotic
+ ErmT confers_resistance_to_antibiotic
+ ErmX confers_resistance_to_antibiotic
+ Erm(33) confers_resistance_to_antibiotic
+ Erm(34) confers_resistance_to_antibiotic
+ Erm(38) confers_resistance_to_antibiotic
+ Erm(39) confers_resistance_to_antibiotic
+ Erm(41) confers_resistance_to_antibiotic
+ Erm(35) confers_resistance_to_antibiotic
+ Erm(36) confers_resistance_to_antibiotic
+ cipA confers_resistance_to_antibiotic
+ cfrA confers_resistance_to_antibiotic
+ clbA confers_resistance_to_antibiotic
+ clbB confers_resistance_to_antibiotic
+ clbC confers_resistance_to_antibiotic
+ lnuG confers_resistance_to_antibiotic
+ vmlR confers_resistance_to_antibiotic
+ mdtM confers_resistance_to_antibiotic
+ lmrC confers_resistance_to_antibiotic
+ lsaC confers_resistance_to_antibiotic
+ lsaE confers_resistance_to_antibiotic
+ tlrC confers_resistance_to_antibiotic
+ salA confers_resistance_to_antibiotic
+ salB confers_resistance_to_antibiotic
+ salC confers_resistance_to_antibiotic
+ salD confers_resistance_to_antibiotic
+ Erm(47) confers_resistance_to_antibiotic
+ Erm(O)-lrm confers_resistance_to_antibiotic
+ ErmH confers_resistance_to_antibiotic
+ ErmO-srmA confers_resistance_to_antibiotic
+ ErmS confers_resistance_to_antibiotic
+ ErmU confers_resistance_to_antibiotic
+ LnuP confers_resistance_to_antibiotic
+ lin confers_resistance_to_antibiotic
+ linG confers_resistance_to_antibiotic
+ lnuA confers_resistance_to_antibiotic
+ lnuB confers_resistance_to_antibiotic
+ lnuC confers_resistance_to_antibiotic
+ lnuD confers_resistance_to_antibiotic
+ lnuE confers_resistance_to_antibiotic
+ lnuF confers_resistance_to_antibiotic
+ lsaD confers_resistance_to_antibiotic
+ vga(E) Staphylococcus cohnii confers_resistance_to_antibiotic
+ vgaALC confers_resistance_to_antibiotic
+ vgaC confers_resistance_to_antibiotic
+ LnuH confers_resistance_to_antibiotic
+ Mef(En2) confers_resistance_to_antibiotic
+ Clostridioides difficile cplR confers_resistance_to_antibiotic
+ Clostridium perfringes cplR confers_resistance_to_antibiotic
+ lmrAB Operon confers_resistance_to_antibiotic
Publications

Roberts MC, et al. 1999. Antimicrob Agents Chemother 43(12): 2823-2830. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. (PMID 10582867)

Doktor SZ, et al. 2004. Diagn Microbiol Infect Dis 49(1): 47-52. Epidemiology of macrolide and/or lincosamide resistant Streptococcus pneumoniae clinical isolates with ribosomal mutations. (PMID 15135500)