| Accession | ARO:3002879 |
| CARD Short Name | linG |
| Definition | linG is an integron-associated gene cassette, with aadA2, encoding a lincosomide nucleotidyltransferase found in Salmonella enterica. linG confers resistance to lincosomide antibiotics. |
| AMR Gene Family | lincosamide nucleotidyltransferase (LNU) |
| Drug Class | lincosamide antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Citrobacter freundiiwgs, Enterobacter asburiaewgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter roggenkampiip, Escherichia albertiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniiwgs, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaewgs, Proteus mirabilisg+wgs, Proteus vulgarisp, Salmonella entericag+p+wgs, Shigella flexnerip, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Citrobacter freundiiwgs, Enterobacter asburiaewgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter roggenkampiip, Escherichia albertiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniig+p+wgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Proteus mirabilisg+wgs, Proteus vulgarisp, Providencia rettgerig+p+wgs, Salmonella entericag+p+wgs, Shigella boydiiwgs, Shigella flexnerip, Shigella sonneiwgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + determinant of antibiotic resistance + antibiotic inactivation enzyme + nucleotidylation of antibiotic conferring resistance + lincosamide antibiotic [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show + lincosamide nucleotidyltransferase (LNU) [AMR Gene Family] + confers_resistance_to_antibiotic lincomycin [Antibiotic] |
| Publications | Levings RS, et al. 2006. Antimicrob Agents Chemother 50(10): 3514-3515. linG, a new integron-associated gene cassette encoding a lincosamide nucleotidyltransferase. (PMID 17005845) |
Prevalence of linG among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter freundii | 0% | 0% | 0.48% | 0% |
| Enterobacter asburiae | 0% | 0% | 0.44% | 0% |
| Enterobacter cloacae | 0% | 0.62% | 0.72% | 0% |
| Enterobacter hormaechei | 0% | 0.13% | 0.18% | 0% |
| Enterobacter roggenkampii | 0% | 0.55% | 0% | 0% |
| Escherichia albertii | 0% | 2.56% | 1.08% | 0% |
| Escherichia coli | 0.05% | 0.35% | 1.17% | 0% |
| Escherichia fergusonii | 1.75% | 0.75% | 9.86% | 0% |
| Klebsiella pneumoniae | 0% | 0.01% | 0.18% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.33% | 0% |
| Proteus mirabilis | 3.3% | 0% | 3.72% | 0% |
| Proteus vulgaris | 0% | 12.5% | 0% | 0% |
| Providencia rettgeri | 3.12% | 2.78% | 5.15% | 0% |
| Salmonella enterica | 0.22% | 1.15% | 1.03% | 0% |
| Shigella boydii | 0% | 0% | 1.1% | 0% |
| Shigella flexneri | 0% | 1.71% | 0% | 0% |
| Shigella sonnei | 0% | 0% | 0.44% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500