lincosamide nucleotidyltransferase (LNU) [AMR Gene Family]

Accession ARO:3000221
DefinitionResistance to the lincosamide antibiotic by ATP-dependent modification of the 3' and/or 4'-hydroxyl groups of the methylthiolincosamide sugar.
Drug Classlincosamide antibiotic
Resistance Mechanismantibiotic inactivation
Classification5 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ antibiotic inactivation enzyme
+ participates_in nucleotidylation of antibiotic conferring resistance
+ confers_resistance_to_drug_class lincosamide antibiotic [Drug Class]
11 ontology terms | Show
+ lnuA
+ lnuB
+ lnuC
+ lnuD
+ lnuF
+ linG
+ LnuP
+ LnuH
+ lnuE
+ lnuG
+ lin

Leclercq R and Leclercq R. 2002. Clin Infect Dis 34(4): 482-492. Mechanisms of resistance to macrolides and lincosamides: nature of the resistance elements and their clinical implications. (PMID 11797175)