| Accession | ARO:3002836 |
| Synonym(s) | linB |
| CARD Short Name | lnuB |
| Definition | lnuB is a plasmid-mediated nucleotidyltransferase found in Streptococcus lutetiensis. |
| AMR Gene Family | lincosamide nucleotidyltransferase (LNU) |
| Drug Class | lincosamide antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Campylobacter coliwgs, Campylobacter jejuniwgs, Enterococcus faecalisg+p+wgs, Enterococcus faeciump+wgs, Enterococcus hiraeg+p+wgs, Erysipelothrix rhusiopathiaeg, Jeotgalibaca arthritidisg, Klebsiella pneumoniaewgs, Listeria innocuap, Staphylococcus aureusg+p+wgs, Staphylococcus epidermidiswgs, Staphylococcus pseudintermediuswgs, Staphylococcus saprophyticusp+wgs, Streptococcus agalactiaeg+wgs, Streptococcus dysgalactiaeg+wgs, Streptococcus equiwgs, Streptococcus gallolyticusg+wgs, Streptococcus lutetiensiswgs, Streptococcus pasteurianusg+wgs, Streptococcus porcinuswgs, Streptococcus suisg+wgs, Streptococcus uberiswgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + lincosamide antibiotic [Drug Class] + nucleotidylation of antibiotic conferring resistance |
| Parent Term(s) | 3 ontology terms | Show + lincosamide nucleotidyltransferase (LNU) [AMR Gene Family] + confers_resistance_to_antibiotic lincomycin [Antibiotic] + confers_resistance_to_antibiotic clindamycin [Antibiotic] |
| Publications | Almuzara M, et al. 2013. J Clin Microbiol 51(12): 4259-4261. First case of Streptococcus lutetiensis bacteremia involving a clindamycin-resistant isolate carrying the lnuB gene. (PMID 24048528) Bozdogan B, et al. 1999. Antimicrob Agents Chemother 43(4): 925-929. A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025. (PMID 10103201) |
Prevalence of lnuB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Campylobacter coli | 0% | 0% | 0.09% | 0% |
| Campylobacter jejuni | 0% | 0% | 0.05% | 0% |
| Enterococcus faecalis | 5.45% | 2.96% | 3.57% | 0% |
| Enterococcus faecium | 0% | 2.78% | 5.94% | 0% |
| Enterococcus hirae | 7.69% | 7.14% | 3.24% | 0% |
| Erysipelothrix rhusiopathiae | 27.27% | 0% | 0% | 0% |
| Jeotgalibaca arthritidis | 100% | 0% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% |
| Listeria innocua | 0% | 10.53% | 0% | 0% |
| Staphylococcus aureus | 2.36% | 0.04% | 1.41% | 0% |
| Staphylococcus epidermidis | 0% | 0% | 0.08% | 0% |
| Staphylococcus pseudintermedius | 0% | 0% | 0.77% | 0% |
| Staphylococcus saprophyticus | 0% | 2.7% | 0.7% | 0% |
| Streptococcus agalactiae | 4.67% | 0% | 3.67% | 0% |
| Streptococcus dysgalactiae | 2% | 0% | 2.8% | 0% |
| Streptococcus equi | 0% | 0% | 0.23% | 0% |
| Streptococcus gallolyticus | 10% | 0% | 6.82% | 0% |
| Streptococcus lutetiensis | 0% | 0% | 2.04% | 0% |
| Streptococcus pasteurianus | 50% | 0% | 15% | 0% |
| Streptococcus porcinus | 0% | 0% | 33.33% | 0% |
| Streptococcus suis | 6.4% | 0% | 3.78% | 0% |
| Streptococcus uberis | 0% | 0% | 4.46% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500