clindamycin [Antibiotic]

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Accession ARO:0000066
Synonym(s)Clindamycinum Cleocin Clindamycine CLI Clindamicina Chlolincocin Clinimycin Sobelin Chlorlincocin
DefinitionClindamycin is a lincosamide antibiotic that blocks A-site aminoacyl-tRNA binding. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria.
Drug Classlincosamide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ lincosamide antibiotic [Drug Class]
Sub-Term(s)
35 ontology terms | Show
+ antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by_antibiotic
+ lsaA confers_resistance_to_antibiotic
+ ErmC confers_resistance_to_antibiotic
+ ErmC' confers_resistance_to_antibiotic
+ ErmE confers_resistance_to_antibiotic
+ ErmA confers_resistance_to_antibiotic
+ ErmB confers_resistance_to_antibiotic
+ Erm(37) confers_resistance_to_antibiotic
+ ErmD confers_resistance_to_antibiotic
+ ErmF confers_resistance_to_antibiotic
+ ErmG confers_resistance_to_antibiotic
+ ErmI confers_resistance_to_antibiotic
+ ErmN confers_resistance_to_antibiotic
+ ErmQ confers_resistance_to_antibiotic
+ ErmR confers_resistance_to_antibiotic
+ ErmT confers_resistance_to_antibiotic
+ ErmX confers_resistance_to_antibiotic
+ Erm(31) confers_resistance_to_antibiotic
+ Erm(33) confers_resistance_to_antibiotic
+ Erm(34) confers_resistance_to_antibiotic
+ Erm(38) confers_resistance_to_antibiotic
+ Erm(39) confers_resistance_to_antibiotic
+ Erm(41) confers_resistance_to_antibiotic
+ Erm(35) confers_resistance_to_antibiotic
+ Erm(36) confers_resistance_to_antibiotic
+ cfr(B) confers_resistance_to_antibiotic
+ LlmA 23S ribosomal RNA methyltransferase confers_resistance_to_antibiotic
+ cipA confers_resistance_to_antibiotic
+ cfrA confers_resistance_to_antibiotic
+ clbA confers_resistance_to_antibiotic
+ clbB confers_resistance_to_antibiotic
+ clbC confers_resistance_to_antibiotic
+ clcD confers_resistance_to_antibiotic
+ Escherichia coli 23S rRNA with mutation conferring resistance to clindamycin confers_resistance_to_antibiotic
+ Clostridioides difficile 23S rRNA with mutation conferring resistance to erythromycin and clindamycin confers_resistance_to_antibiotic
Publications

Dunkle JA, et al. 2010. Proc Natl Acad Sci U S A 107(40): 17152-17157. Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. (PMID 20876128)