vgaE

Accession ARO:3002833
CARD Short NamevgaE
DefinitionvgaE is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with transposon DNA.
AMR Gene Familyvga-type ABC-F protein
Drug Classstreptogramin antibiotic, pleuromutilin antibiotic, streptogramin A antibiotic, lincosamide antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Perfect MatchesStaphylococcus aureusg+wgs+gi
Resistomes with Sequence VariantsStaphylococcus aureusg+wgs+gi
Classification11 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic clindamycin [Antibiotic]
+ vga-type ABC-F protein [AMR Gene Family]
+ confers_resistance_to_antibiotic virginiamycin M1 [Antibiotic]
+ confers_resistance_to_antibiotic tiamulin [Antibiotic]
Publications

Schwendener S, et al. 2011. Antimicrob Agents Chemother 55(10): 4900-4904. New transposon Tn6133 in methicillin-resistant Staphylococcus aureus ST398 contains vga(E), a novel streptogramin A, pleuromutilin, and lincosamide resistance gene. (PMID 21768510)

Resistomes

Prevalence of vgaE among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Staphylococcus aureus0.79%0%0.33%2.87%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 1020


>gb|CBY88983.1|+|vgaE [Staphylococcus aureus subsp. aureus ST398]
MLLFEGTSLKKHIQDRLLFDIDLIQVHEHQRIGLVGRNGTGKTSLLKIITGEELVDGGNVNHFTSVKLVPQFKETRSEKSGGEITQQYLQ
LAFNEKPGLLILDEPTTHLDTQRIDWLEKKLANYQGAFVVVSHDRTFLNNVCTEIWEIEDGSLNAFKGDYNAYAEQKELIKTQQQIAFEK
YEREKKQLEKAIRQKEERAQRATKKPKNLSSSEARITGAKTHYANIQKKLRGSAKALETRLEQLDRIDKVKELPEIKMDILNKESLTNQS
VLRAENIKGEVDGRKLWNPFSLYLYGGDKVAIIGKNGTGKTTLLKKIVERDERIAIPEKVRIGYFSQHLTILDDDKTIIENIQLTSSQDE
TLIRTVLARMHFWDEDVYKKVGILSGGEKVKVALAKLFLSDVNMLVLDEPTNFLDIESLEALETLMKSYHGTILFVTHDRTLVTNIATKI
IDIKDGKITVFDGSYEAYEEWLENQTKSNNDDQLLLIETKISDVLGRLSLEPSRELEDEFQRLLKEKKELTKKL


>gb|FR772051.1|+|8741-10315|vgaE [Staphylococcus aureus subsp. aureus ST398]
ATGTTATTATTTGAAGGTACATCATTGAAAAAACACATACAAGACAGATTATTATTTGATATAGATTTAATACAAGTACATGAACATCAG
CGAATAGGATTAGTAGGTAGGAATGGAACGGGGAAAACAAGTCTATTAAAAATTATTACAGGTGAAGAACTAGTTGATGGAGGGAATGTT
AATCATTTTACCTCTGTAAAATTAGTACCACAATTTAAAGAAACAAGATCGGAGAAAAGTGGTGGAGAAATAACGCAACAATATTTGCAA
TTAGCATTTAATGAAAAGCCAGGATTATTAATTTTAGATGAACCAACGACTCATTTAGATACACAAAGAATTGATTGGTTAGAAAAGAAA
TTAGCAAACTATCAAGGAGCATTTGTTGTCGTATCACATGATCGGACATTTCTAAATAATGTGTGTACTGAAATATGGGAAATAGAAGAT
GGTAGTCTAAACGCGTTTAAAGGGGATTATAATGCTTATGCGGAACAAAAGGAATTAATAAAAACACAGCAGCAGATTGCATTTGAAAAG
TACGAACGAGAGAAAAAGCAATTAGAAAAAGCAATACGACAAAAAGAGGAAAGAGCACAGCGAGCAACAAAGAAACCTAAAAATCTGAGT
TCTTCAGAGGCAAGAATAACAGGAGCTAAAACCCATTATGCCAATATACAGAAAAAGTTGAGGGGTTCTGCAAAAGCATTAGAAACAAGG
TTGGAACAACTGGATAGGATTGACAAGGTGAAAGAACTACCTGAAATTAAGATGGATATATTAAATAAAGAAAGTCTAACAAACCAGTCT
GTGTTACGCGCTGAAAACATTAAGGGAGAGGTTGACGGACGTAAGCTTTGGAATCCCTTTAGTTTATATTTATATGGCGGCGATAAAGTT
GCTATCATTGGGAAAAATGGCACGGGTAAAACAACCTTACTTAAAAAAATAGTTGAGCGAGATGAAAGAATAGCAATCCCAGAAAAGGTG
AGGATAGGTTATTTTTCCCAACACCTCACAATTCTCGATGATGATAAAACAATCATAGAAAATATACAATTGACCTCTAGTCAGGATGAA
ACATTAATTAGAACAGTTTTAGCAAGAATGCATTTTTGGGATGAAGATGTCTATAAAAAGGTCGGCATATTAAGTGGTGGTGAAAAAGTA
AAAGTAGCACTAGCTAAACTATTCTTAAGTGACGTGAATATGCTGGTGTTAGATGAACCTACAAATTTTTTAGATATTGAATCTTTAGAA
GCGCTAGAAACATTAATGAAAAGTTATCATGGAACGATTCTATTTGTTACTCACGACCGAACGTTAGTAACAAATATAGCTACAAAAATA
ATTGATATAAAAGATGGTAAGATAACAGTATTCGATGGATCATACGAAGCATATGAAGAGTGGTTAGAGAATCAAACAAAGTCCAACAAT
GATGATCAACTTTTACTAATCGAAACTAAAATATCTGACGTTCTGGGTAGGTTGAGTTTGGAGCCTTCACGAGAGTTAGAAGATGAATTT
CAAAGATTATTGAAAGAAAAGAAAGAACTGACTAAAAAACTATAA

Curator Acknowledgements
Curator Description Most Recent Edit