vga-type ABC-F protein [AMR Gene Family]

Accession ARO:3000113
DefinitionVga-type plasmid-borne ABC-F proteins, expressed in staphylococci that confer resistance to streptogramin A antibiotics through ribosomal protection.
Drug Classstreptogramin antibiotic, streptogramin A antibiotic, pleuromutilin antibiotic
Resistance Mechanismantibiotic target protection
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ ABC-F ATP-binding cassette ribosomal protection protein
+ confers_resistance_to_drug_class streptogramin A antibiotic [Drug Class]
+ confers_resistance_to_drug_class pleuromutilin antibiotic [Drug Class]
7 ontology terms | Show

Chesneau O, et al. 2005. Antimicrob Agents Chemother 49(3): 973-980. Molecular analysis of resistance to streptogramin A compounds conferred by the Vga proteins of staphylococci. (PMID 15728891)

Kadlec K, et al. 2010. J. Antimicrob. Chemother. 65(12):2692-3 Small plasmids carrying vga(A) or vga(C) genes mediate resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillin-resistant Staphylococcus aureus ST398 from swine. (PMID 20876620)

Schwendener S, et al. 2011. Antimicrob Agents Chemother 55(10): 4900-4904. New transposon Tn6133 in methicillin-resistant Staphylococcus aureus ST398 contains vga(E), a novel streptogramin A, pleuromutilin, and lincosamide resistance gene. (PMID 21768510)