vgaC

Accession ARO:3002831
CARD Short NamevgaC
DefinitionvgaC is an ABC-F subfamily protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA.
AMR Gene Familyvga-type ABC-F protein
Drug Classstreptogramin antibiotic, pleuromutilin antibiotic, streptogramin A antibiotic
Resistance Mechanismantibiotic target protection
Classification10 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ vga-type ABC-F protein [AMR Gene Family]
Publications

Novotna G and Janata J. 2006. Antimicrob Agents Chemother 50(12): 4070-4076. A new evolutionary variant of the streptogramin A resistance protein, Vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamides. (PMID 17015629)

Resistomes

Prevalence of vgaC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 263 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1000


>gb|CBL58195.1|+|vgaC [Staphylococcus aureus]
MVLLEAKNIKHYIKDRLLLKIDELKIEHNDRIGLVGVNGSGKTTLLNILAEKFIPDEGTITPYAQSEILPQLKKTDAAKSGGEITQEYIQ
QTLNSAPALLLADEPTTNLDTDHIEWVEKKLKRWQGAFVLVSHDREFLDALCSVIWELEDGEITEYKGNYSDYLKQKEVEKQQQQSTYEK
YEKEKKQLEKAIQLKEEKAQRATKKPKNLSASERRIKGSKPYFAKKQKKLHKTAGALETRVEKLEKVEKIKDQPPIKMDLPNERNLKNRV
IIRVEDLEGLVPKQLLWKKATFQIYGGDKLAIIGPNGSGKTTLVKKIITQENGVTISPSVKIGYFSQNLMTLDVNKSILENVQNSSKQEE
SLIRTVLARMHFFDEDVYKPVHVLSGGERVKVALTKLLVSDINTLVLDEPTNYLDTEALKALENLLNEYTGSIIFVSHDRTFTENIATRI
LEIRNKKIEIFDGTYQQFKNRSTKKERDFQQEEQLLLDTKISEVLSRLSMEPSQALEKEFQNLLKEKSKLKE


>gb|FN806792.1|+|101-1669|vgaC [Staphylococcus aureus]
ATGGTTTTACTAGAGGCCAAAAATATAAAACACTACATCAAAGATCGCTTATTATTAAAGATTGATGAATTAAAAATTGAACATAATGAC
CGGATTGGCTTGGTAGGTGTAAATGGAAGTGGAAAAACAACTTTGTTAAATATCCTTGCTGAAAAATTTATTCCTGACGAGGGGACAATC
ACGCCGTATGCCCAGAGTGAGATATTGCCACAGTTAAAAAAGACCGATGCGGCAAAAAGTGGGGGCGAAATTACTCAGGAATATATTCAA
CAAACGTTAAATAGTGCTCCAGCTCTTTTATTAGCAGACGAACCGACGACCAATCTAGATACAGATCATATCGAATGGGTTGAAAAAAAA
TTGAAGCGTTGGCAGGGGGCCTTCGTTCTTGTTTCCCATGACCGAGAATTTTTAGACGCTCTGTGTTCTGTTATTTGGGAACTGGAAGAT
GGTGAAATAACGGAGTACAAGGGCAATTATAGTGATTATCTCAAGCAAAAAGAAGTAGAAAAGCAACAACAACAATCCACATATGAAAAA
TATGAAAAAGAAAAAAAACAGCTGGAGAAAGCAATCCAACTAAAAGAAGAAAAGGCCCAACGAGCAACTAAAAAGCCTAAAAATTTATCT
GCTTCTGAGAGACGAATAAAGGGATCGAAGCCTTACTTCGCAAAAAAACAGAAAAAACTGCATAAAACTGCAGGTGCTCTTGAAACAAGA
GTAGAGAAATTAGAAAAAGTAGAGAAAATAAAAGATCAGCCACCTATTAAAATGGATTTACCAAATGAAAGAAATCTTAAAAATCGTGTG
ATTATTCGGGTTGAGGATCTAGAAGGACTTGTTCCCAAGCAGTTACTTTGGAAAAAGGCAACTTTTCAAATTTATGGTGGGGACAAACTA
GCTATCATAGGACCCAATGGTAGTGGAAAAACAACTTTAGTTAAAAAAATAATAACTCAAGAAAATGGTGTCACTATTTCTCCGTCTGTT
AAGATCGGTTACTTTAGTCAGAATCTAATGACGCTAGATGTAAACAAATCTATTTTAGAGAACGTTCAAAATTCTTCGAAACAAGAAGAA
TCACTGATTCGAACGGTACTAGCTAGAATGCATTTCTTTGATGAAGATGTATACAAACCTGTGCATGTGCTAAGCGGTGGTGAAAGAGTA
AAAGTTGCACTGACAAAACTATTAGTGAGCGATATCAATACACTCGTTTTAGATGAACCAACGAATTACTTGGATACGGAAGCACTCAAA
GCATTAGAAAACCTCTTGAATGAATATACGGGAAGTATTATTTTTGTTTCTCATGATCGTACCTTTACCGAAAATATCGCTACTCGAATT
TTAGAAATACGTAATAAAAAAATTGAGATATTTGATGGGACGTACCAACAATTCAAAAATAGATCTACTAAAAAGGAACGGGATTTTCAG
CAAGAAGAGCAGTTACTACTAGATACAAAGATATCCGAAGTACTTAGCCGCTTAAGTATGGAACCTTCCCAAGCTTTGGAAAAAGAATTT
CAAAACCTCCTAAAAGAAAAAAGTAAGTTAAAGGAGTAA