valnemulin [Antibiotic]

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Accession ARO:3001315
DefinitionTwo semi-synthetic pleuromutilin derivatives, tiamulin and valnemulin, have been developed as antibiotics for veterinary use.
Drug Classpleuromutilin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
2 ontology terms | Show
+ vga(E) Staphylococcus cohnii confers_resistance_to_antibiotic
+ vgaC confers_resistance_to_antibiotic

Tang YZ, et al. 2012. Mini Rev Med Chem 12(1): 53-61. Pleuromutilin and its derivatives-the lead compounds for novel antibiotics. (PMID 22070694)

Poulsen SM, et al. 2001. Mol Microbiol 41(5): 1091-1099. The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome. (PMID 11555289)