| Accession | ARO:3000670 |
| Definition | Pleuromutilins are natural fungal products that target bacterial protein translation by binding the the 23S rRNA, blocking the ribosome P site at the 50S subunit. They are mostly used for agriculture and veterinary purposes. |
| Classification | 1 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 13 ontology terms | Show + tiamulin [Antibiotic] + retapamulin [Antibiotic] + valnemulin [Antibiotic] + azamulin [Antibiotic] + pleuromutilin [Antibiotic] + lefamulin [Antibiotic] + antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by + 23S rRNA with mutation conferring resistance to pleuromutilin antibiotics [AMR Gene Family] confers_resistance_to_drug_class + 23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family] confers_resistance_to_drug_class + Ribosomal protein mutation conferring resistance to pleuromutilin antibiotics [AMR Gene Family] confers_resistance_to_drug_class + sal-type ABC-F protein [AMR Gene Family] confers_resistance_to_drug_class + vga-type ABC-F protein [AMR Gene Family] confers_resistance_to_drug_class + lsa-type ABC-F protein [AMR Gene Family] confers_resistance_to_drug_class |
| Publications | Novak R and Shlaes DM. 2010. Curr Opin Investig Drugs 11(2): 182-191. The pleuromutilin antibiotics: a new class for human use. (PMID 20112168) Riedl K. 1976. J Antibiot (Tokyo) 29(2): 132-139. Studies on pleuromutilin and some of its derivatives. (PMID 931799) Long KS, et al. 2006. Antimicrob Agents Chemother 50(4): 1458-1462. Interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center. (PMID 16569865) Schlunzen F, et al. 2004. Mol Microbiol 54(5): 1287-1294. Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin. (PMID 15554968) Davidovich C, et al. 2007. Proc Natl Acad Sci U S A 104(11): 4291-4296. Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity. (PMID 17360517) Poulsen SM, et al. 2001. Mol Microbiol 41(5): 1091-1099. The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome. (PMID 11555289) |
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