retapamulin [Antibiotic]

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Accession ARO:3001314
DefinitionRetapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections.
Drug Classpleuromutilin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
10 ontology terms | Show
+ salA confers_resistance_to_antibiotic
+ salB confers_resistance_to_antibiotic
+ salC confers_resistance_to_antibiotic
+ salD confers_resistance_to_antibiotic
+ salE confers_resistance_to_antibiotic
+ vga(E) Staphylococcus cohnii confers_resistance_to_antibiotic
+ vmlR confers_resistance_to_antibiotic
+ Clostridium perfringes cplR confers_resistance_to_antibiotic
+ Clostridium sporogenes cplR confers_resistance_to_antibiotic
+ Neobacillus vireti vmlR2 confers_resistance_to_antibiotic

Yan K, et al. 2006. Antimicrob Agents Chemother 50(11): 3875-3881. Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes. (PMID 16940066)

Jones RN, et al. 2006. Antimicrob Agents Chemother 50(7): 2583-2586. Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci. (PMID 16801451)

Rittenhouse S, et al. 2006. Antimicrob Agents Chemother 50(11): 3882-3885. Selection of retapamulin, a novel pleuromutilin for topical use. (PMID 17065625)

Davidovich C, et al. 2007. Proc Natl Acad Sci U S A 104(11): 4291-4296. Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity. (PMID 17360517)