salC

Accession ARO:3007027
Synonym(s)sal(C)
CARD Short NamesalC
DefinitionsalC is a ABC-F subfamily protein gene that confers resistance to lincosamides and class A streptogramins.
AMR Gene Familysal-type ABC-F protein
Drug Classstreptogramin antibiotic, lincosamide antibiotic, pleuromutilin antibiotic, streptogramin A antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Sequence VariantsMacrococcus canisg+wgs
Classification11 ontology terms | Show
Parent Term(s)6 ontology terms | Show
+ confers_resistance_to_antibiotic retapamulin [Antibiotic]
+ confers_resistance_to_antibiotic tiamulin [Antibiotic]
+ confers_resistance_to_antibiotic lincomycin [Antibiotic]
+ confers_resistance_to_antibiotic clindamycin [Antibiotic]
+ sal-type ABC-F protein [AMR Gene Family]
+ confers_resistance_to_antibiotic virginiamycin M1 [Antibiotic]
Publications

Mohamad M, et al. 2022. Nucleic Acids Res 50(4):2128-2142 Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci. (PMID 35137182)

Resistomes

Prevalence of salC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Macrococcus canis64.29%0%12.5%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|MBW0764195.1|-|salC [Mammaliicoccus fleurettii]
MLFLFEKKSLEIDNKLLIPSLTFIIEENEHLAIVGINGIGKSTLLNKIHHKENIETAMMEQDLTKYGTLNVMEYIMLTYPQLSSLRENLS
DLDNINRYIELDGYEIEQNIIIEGKKLGLTERHFDQLISTLSGGEQTKVSFLKVKLDKARLLLIDEPTNHMDEEMKVWLTNAFKQEKRAI
LFVSHDKTFLNETPDAILELSSSGATKYSGQYDNYKQQKDLEYKTIKLQYEKQEKEQRAIEETIKKYKEWYQKASQKASVRNPYQQKQLS
KLAKKFKSKEYQMNKKLEQTNLSDPEEEGKTFSMQHHAFKSHYLVKFKNVTFSYNEKPIFNDVSFHIKRNQNVIIEGQNGSGKSTLIKLI
LGQLTPDEGEVIVHPELEIGYFSQDFNNLNMKNTVLEEIMSIQEMKEAEARTILANYYFNENRINDVVANLSMGEKCRIQFVKLYFSNPH
ILILDEPTNYFDIEMQEKIIQLIQSFQGSTLIISHDKYFKEKLKDQIWTIKNLDLVHENLKIENPLNADSIKNQLNELEQYTDERNRETE
F


>gb|JAAQPD010000007.1|-|115793-117418|salC [Mammaliicoccus fleurettii]
ATGCTATTTTTATTTGAAAAAAAGTCTTTAGAGATTGACAATAAACTGCTCATACCTTCACTAACATTTATTATTGAAGAAAATGAACAT
TTGGCAATAGTCGGCATAAATGGTATCGGAAAATCTACACTTTTAAATAAAATCCATCATAAAGAAAATATTGAAACAGCAATGATGGAA
CAAGATTTAACTAAATATGGAACTTTAAATGTCATGGAGTATATTATGTTAACTTATCCACAATTATCATCGTTAAGAGAAAATCTAAGT
GATTTGGATAATATAAATAGATATATTGAATTAGACGGTTACGAAATTGAGCAAAACATTATAATTGAAGGAAAAAAGTTAGGATTAACA
GAAAGGCACTTTGATCAATTAATTTCTACTTTAAGTGGTGGTGAGCAAACAAAAGTTTCGTTTTTGAAAGTTAAATTAGATAAAGCACGA
TTATTATTAATTGATGAACCAACTAACCATATGGATGAAGAAATGAAAGTATGGTTAACTAATGCATTTAAACAAGAAAAACGTGCAATA
TTATTTGTTTCTCACGATAAGACTTTTTTAAATGAAACACCAGACGCAATTTTGGAACTGAGTAGTAGTGGTGCAACAAAATACTCAGGT
CAGTATGACAATTACAAGCAACAAAAAGATTTAGAATATAAAACGATTAAGCTACAATACGAAAAACAAGAAAAAGAGCAACGAGCAATT
GAAGAAACAATTAAAAAATATAAAGAATGGTATCAAAAAGCTTCACAAAAAGCTTCAGTAAGAAATCCTTATCAACAAAAACAACTTAGC
AAGCTTGCGAAAAAGTTTAAATCGAAAGAATATCAAATGAATAAAAAACTTGAACAAACCAATTTATCAGATCCTGAAGAGGAAGGAAAA
ACATTTTCAATGCAACATCACGCCTTCAAATCTCATTATTTAGTTAAATTTAAAAATGTGACATTTTCATATAATGAAAAGCCTATTTTT
AATGATGTCTCTTTTCATATTAAGCGAAATCAAAATGTTATCATTGAAGGTCAAAATGGCTCAGGTAAATCTACTTTGATCAAGTTGATA
CTAGGTCAACTGACACCTGATGAGGGAGAAGTAATCGTACATCCTGAATTAGAAATAGGTTATTTTTCACAAGATTTTAATAACTTAAAT
ATGAAAAATACTGTGTTAGAAGAAATAATGTCTATTCAAGAAATGAAAGAAGCGGAAGCAAGAACAATTTTAGCGAATTATTATTTTAAT
GAAAATAGAATTAATGATGTTGTTGCCAATTTATCTATGGGTGAAAAATGTAGAATACAGTTTGTTAAATTGTATTTTTCAAATCCACAT
ATACTCATATTAGATGAGCCAACTAACTATTTTGATATTGAAATGCAAGAAAAAATCATACAATTAATTCAATCTTTTCAAGGATCAACA
CTTATCATTTCACATGATAAATATTTTAAAGAAAAGCTTAAAGATCAAATTTGGACAATAAAGAATCTAGATTTGGTACATGAAAATCTT
AAAATTGAGAATCCATTAAATGCTGATTCTATTAAAAATCAATTAAATGAATTAGAGCAATATACCGACGAAAGAAATAGAGAAACAGAG
TTCTAG