sal-type ABC-F protein [AMR Gene Family]

Accession ARO:3007030
DefinitionSal proteins are a part of the ABC-F proteins, expressed in staphylococci that confer resistance to group A streptogramin, lincosamide, and pleuromutilin antibiotics through ribosomal protection.
Drug Classstreptogramin antibiotic, lincosamide antibiotic, pleuromutilin antibiotic, streptogramin A antibiotic
Resistance Mechanismantibiotic target protection
Classification7 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ ABC-F ATP-binding cassette ribosomal protection protein
+ confers_resistance_to_drug_class lincosamide antibiotic [Drug Class]
+ confers_resistance_to_drug_class pleuromutilin antibiotic [Drug Class]
+ confers_resistance_to_drug_class streptogramin A antibiotic [Drug Class]
5 ontology terms | Show
+ salA
+ salB
+ salC
+ salD
+ salE

Mohamad M, et al. 2022. Nucleic Acids Res 50(4):2128-2142 Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci. (PMID 35137182)