streptogramin A antibiotic [Drug Class]

Accession ARO:0000034
DefinitionStreptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics.
Drug Classstreptogramin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
7 ontology terms | Show
+ virginiamycin M1 [Antibiotic]
+ madumycin II [Antibiotic]
+ griseoviridin [Antibiotic]
+ dalfopristin [Antibiotic]
+ antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by
+ sal-type ABC-F protein [AMR Gene Family] confers_resistance_to_drug_class
+ vga-type ABC-F protein [AMR Gene Family] confers_resistance_to_drug_class

Novotna G and Janata J. 2006. Antimicrob Agents Chemother 50(12): 4070-4076. A new evolutionary variant of the streptogramin A resistance protein, Vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamides. (PMID 17015629)

Hansen JL, et al. 2003. J Mol Biol 330(5): 1061-1075. Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit. (PMID 12860128)

Johnston NJ, et al. 2002. Curr Drug Targets 3(4): 335-344. Streptogramin antibiotics: mode of action and resistance. (PMID 12102603)

Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955)