| Accession | ARO:0000034 |
| Definition | Streptogramin A antibiotics are cyclic polyketide peptide hybrids that bind to the ribosomal peptidyl transfer centre. Structural variation arises from substituting a proline for its desaturated derivative and by its substitution for Ala or Cys. Used alone, streptogramin A antibiotics are bacteriostatic, but is bactericidal when used with streptogramin B antibiotics. |
| Drug Class | streptogramin antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + streptogramin antibiotic [Drug Class] |
| Sub-Term(s) | 7 ontology terms | Show + virginiamycin M1 [Antibiotic] + madumycin II [Antibiotic] + griseoviridin [Antibiotic] + dalfopristin [Antibiotic] + antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by + sal-type ABC-F protein [AMR Gene Family] confers_resistance_to_drug_class + vga-type ABC-F protein [AMR Gene Family] confers_resistance_to_drug_class |
| Publications | Novotna G and Janata J. 2006. Antimicrob Agents Chemother 50(12): 4070-4076. A new evolutionary variant of the streptogramin A resistance protein, Vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamides. (PMID 17015629) Hansen JL, et al. 2003. J Mol Biol 330(5): 1061-1075. Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit. (PMID 12860128) Johnston NJ, et al. 2002. Curr Drug Targets 3(4): 335-344. Streptogramin antibiotics: mode of action and resistance. (PMID 12102603) Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955) |