dalfopristin [Antibiotic]

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Accession ARO:3000674
DefinitionDalfopristin is a water-soluble semi-synthetic derivative of pristinamycin IIA. It is produced by Streptomyces pristinaespiralis and is used in combination with quinupristin in a 7:3 ratio. Both work together to inhibit protein synthesis, and is active against Gram-positive bacteria.
Drug Classstreptogramin antibiotic, streptogramin A antibiotic
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
32 ontology terms | Show
+ antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by_antibiotic
+ lsaA confers_resistance_to_antibiotic
+ vgaB confers_resistance_to_antibiotic
+ streptogramin vat acetyltransferase [AMR Gene Family] confers_resistance_to_antibiotic
+ ErmC confers_resistance_to_antibiotic
+ ErmE confers_resistance_to_antibiotic
+ ErmA confers_resistance_to_antibiotic
+ ErmB confers_resistance_to_antibiotic
+ Erm(37) confers_resistance_to_antibiotic
+ ErmD confers_resistance_to_antibiotic
+ ErmF confers_resistance_to_antibiotic
+ ErmG confers_resistance_to_antibiotic
+ ErmN confers_resistance_to_antibiotic
+ ErmQ confers_resistance_to_antibiotic
+ ErmR confers_resistance_to_antibiotic
+ ErmT confers_resistance_to_antibiotic
+ ErmX confers_resistance_to_antibiotic
+ Erm(33) confers_resistance_to_antibiotic
+ Erm(34) confers_resistance_to_antibiotic
+ Erm(38) confers_resistance_to_antibiotic
+ Erm(39) confers_resistance_to_antibiotic
+ Erm(41) confers_resistance_to_antibiotic
+ Erm(35) confers_resistance_to_antibiotic
+ Erm(36) confers_resistance_to_antibiotic
+ cipA confers_resistance_to_antibiotic
+ cfrA confers_resistance_to_antibiotic
+ clbA confers_resistance_to_antibiotic
+ clbB confers_resistance_to_antibiotic
+ clbC confers_resistance_to_antibiotic
+ vgaD confers_resistance_to_antibiotic
+ lmrP confers_resistance_to_antibiotic
+ quinupristin-dalfopristin [Antibiotic] has_part
Publications

Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955)