clbB

Accession ARO:3002815
CARD Short NameclbB
DefinitionclbB is a plasmid-encoded cfr gene found in Bacillus brevis.
AMR Gene FamilyCfr 23S ribosomal RNA methyltransferase
Drug Classphenicol antibiotic, streptogramin antibiotic, oxazolidinone antibiotic, lincosamide antibiotic, pleuromutilin antibiotic, streptogramin A antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Perfect MatchesBrevibacillus brevisg
Resistomes with Sequence VariantsBrevibacillus brevisg+wgs+gi
Classification17 ontology terms | Show
Parent Term(s)11 ontology terms | Show
+ confers_resistance_to_antibiotic clindamycin [Antibiotic]
+ confers_resistance_to_antibiotic lincomycin [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic tiamulin [Antibiotic]
+ confers_resistance_to_antibiotic dalfopristin [Antibiotic]
+ confers_resistance_to_antibiotic griseoviridin [Antibiotic]
+ confers_resistance_to_antibiotic virginiamycin M1 [Antibiotic]
+ confers_resistance_to_antibiotic madumycin II [Antibiotic]
+ confers_resistance_to_antibiotic azidamfenicol [Antibiotic]
+ confers_resistance_to_antibiotic thiamphenicol [Antibiotic]
+ cfr(B) Group
Publications

Hansen LH, et al. 2012. Antimicrob Agents Chemother 56(7): 3563-3567. The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene. (PMID 22547628)

Pawlowski AC, et al. 2017. ISME J : The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies. (PMID 29259290)

Resistomes

Prevalence of clbB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Brevibacillus brevis100%0%90%100%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 600


>gb|BAH45481.1|-|clbB [Brevibacillus brevis NBRC 100599]
MKLTSKYETIRRILSECKQPEYRYAQIMDAIFKQNIGEYERMTILPKFLRDELNRILGPNVCSIAPVKELTSKQVSKVLFAIPGDEQVEA
VRLTYERGWKSYCISTQCGCGFRCKFCATGTIGLKRNLTADEITDQLLYFRLNGHSLDSISFMGMGEALANPHIFEAMTILTDPYLFGLG
HRRITISTIGLLPGIDKLTREFPQVNLTFSLHSPFDDQRSELMPINDRFPVRDVLIALDRHIRETGRKVYIAYILLRGVNDSTAHAEAVA
ELLRGRGAWEHLYHVNLIPFNSTEVTPDSYRQSDPSRIKAFVRILKSRGISVTVRTQFGSDINAACGQLYRSE


>gb|AP008955.1|-|4758176-4759207|clbB [Brevibacillus brevis NBRC 100599]
ATGAAACTAACCTCGAAATATGAAACGATTCGGCGAATCTTGTCCGAATGCAAGCAGCCTGAGTATCGGTATGCTCAGATTATGGACGCC
ATTTTCAAGCAAAACATCGGCGAATACGAACGGATGACCATCCTACCCAAATTTTTGCGCGACGAGTTGAATCGGATACTTGGACCGAAC
GTTTGCAGTATCGCTCCGGTAAAGGAGCTCACGTCGAAACAGGTTAGCAAGGTGCTGTTTGCGATTCCGGGCGACGAACAGGTCGAGGCC
GTACGACTTACTTATGAACGGGGGTGGAAATCGTATTGTATTTCCACACAGTGCGGCTGCGGATTCAGGTGCAAGTTTTGTGCTACCGGT
ACCATTGGTCTGAAACGAAATCTGACCGCCGACGAAATTACCGACCAATTGCTGTACTTTCGTTTGAACGGCCACTCTTTGGACAGCATC
TCATTCATGGGCATGGGAGAGGCGCTCGCCAACCCGCATATTTTTGAGGCCATGACGATATTGACCGACCCGTATCTCTTCGGTTTAGGA
CATCGACGAATTACGATTTCCACGATCGGCCTGTTGCCGGGGATTGACAAGCTGACTCGGGAGTTCCCCCAGGTCAATCTAACCTTCTCG
CTGCATTCACCGTTCGACGATCAGCGAAGCGAGCTGATGCCGATCAACGACCGATTTCCAGTCCGTGACGTACTGATAGCATTGGATCGT
CACATCAGGGAAACAGGGAGAAAGGTATATATTGCGTATATTCTTCTTCGTGGAGTAAACGACTCGACAGCGCATGCGGAAGCAGTTGCC
GAGTTGCTAAGGGGAAGGGGAGCTTGGGAACATCTCTACCACGTTAACCTGATTCCATTCAATTCGACCGAAGTTACGCCAGACAGCTAT
CGGCAATCCGATCCTTCGCGGATTAAAGCGTTTGTTCGGATCTTGAAGTCAAGGGGGATAAGCGTCACGGTCCGAACTCAATTCGGATCG
GACATAAACGCGGCATGCGGCCAGTTATACCGCTCTGAATAA