clbB

Accession ARO:3002815
DefinitionclbB is a plasmid-encoded cfr gene found in Bacillus brevis
AMR Gene FamilyCfr 23S ribosomal RNA methyltransferase
Drug Classoxazolidinone antibiotic, phenicol antibiotic, macrolide antibiotic, streptogramin antibiotic, lincosamide antibiotic, pleuromutilin antibiotic
Resistance Mechanismantibiotic target alteration
Classification24 ontology terms | Show
Parent Term(s)11 ontology terms | Show
+ confers_resistance_to_antibiotic clindamycin [Antibiotic]
+ confers_resistance_to_antibiotic lincomycin [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic tiamulin [Antibiotic]
+ confers_resistance_to_antibiotic dalfopristin [Antibiotic]
+ confers_resistance_to_antibiotic griseoviridin [Antibiotic]
+ confers_resistance_to_antibiotic pristinamycin IIA [Antibiotic]
+ confers_resistance_to_antibiotic madumycin II [Antibiotic]
+ confers_resistance_to_antibiotic azidamfenicol [Antibiotic]
+ confers_resistance_to_antibiotic thiamphenicol [Antibiotic]
+ cfr(B) Group
Publications

Hansen LH, et al. 2012. Antimicrob Agents Chemother 56(7): 3563-3567. The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene. (PMID 22547628)

Pawlowski AC, et al. 2017. ISME J : The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies. (PMID 29259290)

Resistomes

Prevalence of clbB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 600


>gb|BAH45481.1|-|clbB [Brevibacillus brevis NBRC 100599]
MKLTSKYETIRRILSECKQPEYRYAQIMDAIFKQNIGEYERMTILPKFLRDELNRILGPNVCSIAPVKELTSKQVSKVLFAIPGDEQVEA
VRLTYERGWKSYCISTQCGCGFRCKFCATGTIGLKRNLTADEITDQLLYFRLNGHSLDSISFMGMGEALANPHIFEAMTILTDPYLFGLG
HRRITISTIGLLPGIDKLTREFPQVNLTFSLHSPFDDQRSELMPINDRFPVRDVLIALDRHIRETGRKVYIAYILLRGVNDSTAHAEAVA
ELLRGRGAWEHLYHVNLIPFNSTEVTPDSYRQSDPSRIKAFVRILKSRGISVTVRTQFGSDINAACGQLYRSE


>gb|AP008955.1|-|4758176-4759207|clbB [Brevibacillus brevis NBRC 100599]
ATGAAACTAACCTCGAAATATGAAACGATTCGGCGAATCTTGTCCGAATGCAAGCAGCCTGAGTATCGGTATGCTCAGATTATGGACGCC
ATTTTCAAGCAAAACATCGGCGAATACGAACGGATGACCATCCTACCCAAATTTTTGCGCGACGAGTTGAATCGGATACTTGGACCGAAC
GTTTGCAGTATCGCTCCGGTAAAGGAGCTCACGTCGAAACAGGTTAGCAAGGTGCTGTTTGCGATTCCGGGCGACGAACAGGTCGAGGCC
GTACGACTTACTTATGAACGGGGGTGGAAATCGTATTGTATTTCCACACAGTGCGGCTGCGGATTCAGGTGCAAGTTTTGTGCTACCGGT
ACCATTGGTCTGAAACGAAATCTGACCGCCGACGAAATTACCGACCAATTGCTGTACTTTCGTTTGAACGGCCACTCTTTGGACAGCATC
TCATTCATGGGCATGGGAGAGGCGCTCGCCAACCCGCATATTTTTGAGGCCATGACGATATTGACCGACCCGTATCTCTTCGGTTTAGGA
CATCGACGAATTACGATTTCCACGATCGGCCTGTTGCCGGGGATTGACAAGCTGACTCGGGAGTTCCCCCAGGTCAATCTAACCTTCTCG
CTGCATTCACCGTTCGACGATCAGCGAAGCGAGCTGATGCCGATCAACGACCGATTTCCAGTCCGTGACGTACTGATAGCATTGGATCGT
CACATCAGGGAAACAGGGAGAAAGGTATATATTGCGTATATTCTTCTTCGTGGAGTAAACGACTCGACAGCGCATGCGGAAGCAGTTGCC
GAGTTGCTAAGGGGAAGGGGAGCTTGGGAACATCTCTACCACGTTAACCTGATTCCATTCAATTCGACCGAAGTTACGCCAGACAGCTAT
CGGCAATCCGATCCTTCGCGGATTAAAGCGTTTGTTCGGATCTTGAAGTCAAGGGGGATAAGCGTCACGGTCCGAACTCAATTCGGATCG
GACATAAACGCGGCATGCGGCCAGTTATACCGCTCTGAATAA