| Accession | ARO:3000202 |
| Definition | Cfr genes produce enzymes which catalyze the methylation of the 23S rRNA subunit at position 8 of adenine-2503. Methylation of 23S rRNA at this site confers resistance to some classes of antibiotics, including streptogramins, chloramphenicols, florfenicols, linezolids and clindamycin. |
| Drug Class | lincosamide antibiotic, streptogramin antibiotic, oxazolidinone antibiotic, phenicol antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + antibiotic target modifying enzyme + ribosomal alteration conferring antibiotic resistance + rRNA methyltransferase conferring antibiotic resistance + 23S ribosomal RNA methyltransferase + antibiotic molecule |
| Parent Term(s) | 5 ontology terms | Show + confers_resistance_to_drug_class lincosamide antibiotic [Drug Class] + confers_resistance_to_drug_class streptogramin antibiotic [Drug Class] + confers_resistance_to_drug_class oxazolidinone antibiotic [Drug Class] + confers_resistance_to_drug_class phenicol antibiotic [Drug Class] + S-adenosylmethionine (SAM) superfamily |
| Sub-Term(s) | 5 ontology terms | Show |
| Publications | Morales G, et al. 2010. Clin Infect Dis 50(6): 821-825. Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus. (PMID 20144045) Tsiodras S, et al. 2001. Lancet 358(9277): 207-208. Linezolid resistance in a clinical isolate of Staphylococcus aureus. (PMID 11476839) Nannini E, et al. 2010. Curr Opin Pharmacol 10(5): 516-521. Resistance or decreased susceptibility to glycopeptides, daptomycin, and linezolid in methicillin-resistant Staphylococcus aureus. (PMID 20598637) Toh SM, et al. 2007. Mol Microbiol 64(6): 1506-1514. Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. (PMID 17555436) Atkinson GC, et al. 2013. Antimicrob Agents Chemother 57(8): 4019-4026. Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase. (PMID 23752511) Hansen LH, et al. 2012. Antimicrob Agents Chemother 56(7): 3563-3567. The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene. (PMID 22547628) Candela T, et al. 2017. Int. J. Antimicrob. Agents 50(3):496-500 A cfr-Like Gene cfr(C) Conferring Linezolid Resistance is Common in Clostridium difficile. (PMID 28663118) |
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