Cfr 23S ribosomal RNA methyltransferase [AMR Gene Family]

Accession ARO:3000202
DefinitionCfr genes produce enzymes which catalyze the methylation of the 23S rRNA subunit at position 8 of adenine-2503. Methylation of 23S rRNA at this site confers resistance to some classes of antibiotics, including streptogramins, chloramphenicols, florfenicols, linezolids and clindamycin.
Drug Classoxazolidinone antibiotic, streptogramin antibiotic, phenicol antibiotic, lincosamide antibiotic
Resistance Mechanismantibiotic target alteration
Classification9 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ S-adenosylmethionine (SAM) superfamily
+ confers_resistance_to_drug_class oxazolidinone antibiotic [Drug Class]
+ confers_resistance_to_drug_class streptogramin antibiotic [Drug Class]
+ confers_resistance_to_drug_class phenicol antibiotic [Drug Class]
+ confers_resistance_to_drug_class lincosamide antibiotic [Drug Class]
5 ontology terms | Show

Morales G, et al. 2010. Clin Infect Dis 50(6): 821-825. Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus. (PMID 20144045)

Tsiodras S, et al. 2001. Lancet 358(9277): 207-208. Linezolid resistance in a clinical isolate of Staphylococcus aureus. (PMID 11476839)

Nannini E, et al. 2010. Curr Opin Pharmacol 10(5): 516-521. Resistance or decreased susceptibility to glycopeptides, daptomycin, and linezolid in methicillin-resistant Staphylococcus aureus. (PMID 20598637)

Toh SM, et al. 2007. Mol Microbiol 64(6): 1506-1514. Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. (PMID 17555436)

Atkinson GC, et al. 2013. Antimicrob Agents Chemother 57(8): 4019-4026. Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase. (PMID 23752511)

Hansen LH, et al. 2012. Antimicrob Agents Chemother 56(7): 3563-3567. The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene. (PMID 22547628)

Candela T, et al. 2017. Int. J. Antimicrob. Agents 50(3):496-500 A cfr-Like Gene cfr(C) Conferring Linezolid Resistance is Common in Clostridium difficile. (PMID 28663118)