phenicol antibiotic [Drug Class]

Accession ARO:3000387
Synonym(s)phenicol
DefinitionPhenicols are broad spectrum bacteriostatic antibiotics acting on bacterial protein synthesis. More specifically, the phenicols block peptide elongation by binding to the peptidyltansferase centre of the 70S ribosome.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
12 ontology terms | Show
+ chloramphenicol [Antibiotic]
+ azidamfenicol [Antibiotic]
+ thiamphenicol [Antibiotic]
+ florfenicol [Antibiotic]
+ determinant of phenicol resistance confers_resistance_to_drug_class
+ 23S rRNA with mutation conferring resistance to phenicol antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ chloramphenicol acetyltransferase (CAT) [AMR Gene Family] confers_resistance_to_drug_class
+ chloramphenicol phosphotransferase [AMR Gene Family] confers_resistance_to_drug_class
+ cmlA4 confers_resistance_to_drug_class
+ 23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ ABC-F ATP-binding cassette ribosomal protection protein [AMR Gene Family] confers_resistance_to_drug_class
+ antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by
Publications

Hansen JL, et al. 2003. J Mol Biol 330(5): 1061-1075. Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit. (PMID 12860128)