florfenicol [Antibiotic]

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Accession ARO:3000461
DefinitionFlorfenicol is a fluorine derivative of chloramphenicol, where the nitro group (-NO2) is substituted by a sulfomethyl group (-SO2CH3) and the hydroxyl group (-OH), by a fluorine group (-F). The action mechanism is the same as chloramphenicol's, where the antibiotic binds to the 23S RNA of the 50S subunit of bacterial ribosomes to inhibit protein synthesis.
Drug Classphenicol antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ phenicol antibiotic [Drug Class]
Sub-Term(s)
10 ontology terms | Show
+ antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by_antibiotic
+ clcD confers_resistance_to_antibiotic
+ floR confers_resistance_to_antibiotic
+ pp-flo confers_resistance_to_antibiotic
+ fexA confers_resistance_to_antibiotic
+ flo confers_resistance_to_antibiotic
+ Staphylococcys aureus LmrS confers_resistance_to_antibiotic
+ cfrC confers_resistance_to_antibiotic
+ poxtA confers_resistance_to_antibiotic
+ pexA confers_resistance_to_antibiotic
Publications

Schwarz S, et al. 2004. FEMS Microbiol Rev 28(5): 519-542. Molecular basis of bacterial resistance to chloramphenicol and florfenicol. (PMID 15539072)