| Accession | ARO:3004572 |
| Synonym(s) | A0A3M7YRP9 A0A3P0BBR7 F6MF49 |
| CARD Short Name | Saur_LmrS |
| Definition | MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | aminoglycoside antibiotic, macrolide antibiotic, oxazolidinone antibiotic, phenicol antibiotic, diaminopyrimidine antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Staphylococcus aureusg+wgs |
| Resistomes with Sequence Variants | Enterococcus faecaliswgs, Escherichia coliwgs, Klebsiella pneumoniaewgs, Pseudomonas aeruginosawgs, Salmonella entericawgs, Serratia marcescenswgs, Staphylococcus aureusg+wgs, Staphylococcus epidermidiswgs, Staphylococcus pseudintermediuswgs, Streptococcus pyogeneswgs, Vibrio choleraewgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminoglycoside antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + oxazolidinone antibiotic [Drug Class] + phenicol antibiotic [Drug Class] + diaminopyrimidine antibiotic [Drug Class] |
| Parent Term(s) | 8 ontology terms | Show + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic linezolid [Antibiotic] + confers_resistance_to_antibiotic trimethoprim [Antibiotic] + confers_resistance_to_antibiotic florfenicol [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic streptomycin [Antibiotic] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] |
| Publications | Floyd JL, et al. 2010. Antimicrob. Agents Chemother. 54(12):5406-12 LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. (PMID 20855745) |
Prevalence of Staphylococcus aureus LmrS among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Enterococcus faecalis | 0% | 0% | 0.05% | 0% |
| Escherichia coli | 0% | 0% | 0.02% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.02% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.02% | 0% |
| Salmonella enterica | 0% | 0% | 0.01% | 0% |
| Serratia marcescens | 0% | 0% | 0.14% | 0% |
| Staphylococcus aureus | 100% | 0% | 58.82% | 0% |
| Staphylococcus epidermidis | 0% | 0% | 0.09% | 0% |
| Staphylococcus pseudintermedius | 0% | 0% | 0.26% | 0% |
| Streptococcus pyogenes | 0% | 0% | 0.05% | 0% |
| Vibrio cholerae | 0% | 0% | 0.07% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 800