| Accession | ARO:3004572 |
| Synonym(s) | F6MF49 A0A3P0BBR7 A0A3M7YRP9 |
| Definition | MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | macrolide antibiotic, diaminopyrimidine antibiotic, oxazolidinone antibiotic, phenicol antibiotic, aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Staphylococcus aureusg+wgs |
| Resistomes with Sequence Variants | Escherichia coliwgs, Klebsiella pneumoniaewgs, Salmonella entericawgs, Serratia marcescenswgs, Staphylococcus aureusg+wgs, Staphylococcus epidermidiswgs, Staphylococcus pseudintermediuswgs, Streptococcus pyogeneswgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + macrolide antibiotic [Drug Class] + diaminopyrimidine antibiotic [Drug Class] + oxazolidinone antibiotic [Drug Class] + phenicol antibiotic [Drug Class] + aminoglycoside antibiotic [Drug Class] |
| Parent Term(s) | 8 ontology terms | Show + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic streptomycin [Antibiotic] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic linezolid [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic trimethoprim [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic florfenicol [Antibiotic] |
| Publications | Floyd JL, et al. 2010. Antimicrob. Agents Chemother. 54(12):5406-12 LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. (PMID 20855745) |
Prevalence of Staphylococcus aureus LmrS among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 88 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS |
|---|---|---|---|
| Escherichia coli | 0% | 0% | 0.02% |
| Klebsiella pneumoniae | 0% | 0% | 0.02% |
| Salmonella enterica | 0% | 0% | 0.01% |
| Serratia marcescens | 0% | 0% | 0.18% |
| Staphylococcus aureus | 100% | 0% | 99.47% |
| Staphylococcus epidermidis | 0% | 0% | 0.13% |
| Staphylococcus pseudintermedius | 0% | 0% | 0.47% |
| Streptococcus pyogenes | 0% | 0% | 0.06% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 800