Staphylococcys aureus LmrS

Accession ARO:3004572
Synonym(s)F6MF49 A0A3P0BBR7 A0A3M7YRP9
DefinitionMFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, glycylcycline, aminoglycoside antibiotic, phenicol antibiotic, oxazolidinone antibiotic, antibacterial free fatty acids, rhodamine, lincosamide antibiotic, cephalosporin, macrolide antibiotic, fosfomycin, nucleoside antibiotic, nitroimidazole antibiotic, rifamycin antibiotic, peptide antibiotic, bicyclomycin, diaminopyrimidine antibiotic, penam, benzalkonium chloride, acridine dye, isoniazid, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesStaphylococcus aureusg+wgs
Classification31 ontology terms | Show
Parent Term(s)8 ontology terms | Show
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic streptomycin [Antibiotic]
+ confers_resistance_to_antibiotic kanamycin A [Antibiotic]
+ confers_resistance_to_antibiotic linezolid [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic trimethoprim [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic florfenicol [Antibiotic]
Publications

Floyd JL, et al. 2010. Antimicrob. Agents Chemother. 54(12):5406-12 LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. (PMID 20855745)

Resistomes

Prevalence of Staphylococcys aureus LmrS among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Serratia marcescens0%0%0.23%
Staphylococcus aureus99.76%0%99.4%
Staphylococcus pseudintermedius0%0%0.51%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 800


>gb|AAW38464.1|-|Staphylococcys aureus LmrS [Staphylococcus aureus subsp. aureus COL]
MAKVELTTRRRNFIVAVMLISAFVAILNQTLLNTALPSIMRELNINESTSQWLVTGFMLVNGVMIPLTAYLMDRIKTRPLYLAAMGTFLL
GSIVAALAPNFGVLMLARVIQAMGAGVLMPLMQFTLFTLFSKEHRGFAMGLAGLVIQFAPAIGPTVTGLIIDQASWRVPFIIIVGIAILA
FVFGLVSISSYNEVKYTKLDKRSVMYSTIGFGLMLYAFSSAGDLGFTSPIVIGALILSMVIIYLFIRRQFNITNALLNLRVFKNRTFALC
TISSMIIMMSMVGPALLIPLYVQNSLSLSALLSGLVIMPGAIINGIMSVFTGKFYDKYGPRPLIYTGFTILTITTIMLCFLHTDTSYTYL
IVVYAIRMFSVSLLMMPINTTGINSLRNEEISHGTAIMNFGRVMAGSLGTALMVTLMSFGAKIFLSTSPSHLTATEIKQQSIAIGVDISF
AFVAVLVMAAYVIALFIREPKEIESNRRKF


>gb|CP000046.1|-|2235375-2236817|Staphylococcys aureus LmrS [Staphylococcus aureus subsp. aureus COL]
ATGGCTAAAGTTGAATTAACAACCCGGAGACGAAACTTCATAGTTGCTGTTATGTTGATTAGTGCGTTTGTAGCTATTTTAAATCAAACA
TTATTAAATACAGCGTTACCTAGTATAATGAGAGAATTAAATATCAATGAAAGTACATCGCAATGGCTAGTTACTGGGTTTATGCTTGTT
AATGGCGTCATGATACCTCTGACGGCATATCTAATGGATAGAATTAAAACTAGACCTTTATACTTAGCGGCGATGGGGACATTTTTATTA
GGTTCTATTGTTGCAGCCTTAGCTCCGAATTTTGGAGTTTTAATGTTAGCTCGTGTAATTCAAGCGATGGGTGCAGGCGTACTTATGCCC
TTAATGCAATTTACGTTATTTACATTGTTCAGTAAAGAACATCGAGGTTTTGCAATGGGACTAGCAGGTTTAGTAATTCAATTTGCACCA
GCAATAGGACCTACAGTTACAGGATTAATTATTGATCAAGCGAGTTGGCGAGTTCCATTTATTATAATTGTAGGAATTGCTATACTTGCC
TTTGTTTTCGGTTTGGTTTCAATCTCGAGTTACAATGAAGTGAAATATACGAAATTAGATAAGCGTTCAGTAATGTATTCAACTATTGGG
TTCGGGTTAATGCTATACGCATTTAGTAGTGCAGGAGATTTAGGATTTACAAGTCCAATAGTAATAGGTGCGTTGATATTAAGTATGGTT
ATTATCTATTTATTTATACGTAGACAATTTAATATTACTAATGCACTTTTAAATTTAAGGGTTTTTAAAAATAGAACATTTGCATTATGT
ACGATTAGTTCAATGATTATAATGATGTCAATGGTTGGACCTGCGCTGCTTATACCGCTATATGTTCAAAACAGTTTATCTTTATCTGCC
TTGTTATCAGGACTTGTTATCATGCCTGGTGCAATAATAAATGGTATTATGTCAGTTTTTACAGGTAAATTTTATGATAAGTATGGTCCT
AGACCATTGATTTATACTGGTTTTACAATTTTAACAATTACTACAATTATGTTGTGTTTCTTGCATACAGACACATCTTATACGTATTTA
ATAGTCGTATATGCAATTAGAATGTTTTCAGTTTCTTTACTCATGATGCCGATAAATACTACAGGAATTAATTCTTTGAGAAATGAAGAA
ATCTCACATGGCACGGCTATTATGAACTTTGGTCGTGTAATGGCTGGTTCACTAGGCACAGCTTTAATGGTTACATTAATGAGTTTTGGT
GCAAAAATATTTTTATCTACATCGCCATCGCATTTAACTGCAACTGAAATTAAACAGCAATCCATTGCTATAGGGGTGGATATCTCATTT
GCTTTTGTAGCTGTGCTTGTTATGGCAGCTTATGTGATAGCACTTTTTATAAGAGAACCTAAAGAAATAGAAAGTAATAGAAGGAAATTT
TAA