| Accession | ARO:3004572 |
| Synonym(s) | F6MF49 A0A3P0BBR7 A0A3M7YRP9 |
| Definition | MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | tetracycline antibiotic, glycylcycline, aminoglycoside antibiotic, phenicol antibiotic, oxazolidinone antibiotic, antibacterial free fatty acids, rhodamine, lincosamide antibiotic, cephalosporin, macrolide antibiotic, fosfomycin, nucleoside antibiotic, nitroimidazole antibiotic, rifamycin antibiotic, peptide antibiotic, bicyclomycin, diaminopyrimidine antibiotic, penam, benzalkonium chloride, acridine dye, isoniazid, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes | Staphylococcus aureusg+wgs |
| Classification | 31 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + beta-lactam antibiotic + mechanism of antibiotic resistance + antibiotic without defined classification + antibiotic efflux [Resistance Mechanism] + tetracycline antibiotic [Drug Class] + determinant of antibiotic resistance + cephem + glycylcycline [Drug Class] + aminoglycoside antibiotic [Drug Class] + phenicol antibiotic [Drug Class] + oxazolidinone antibiotic [Drug Class] + antibacterial free fatty acids [Drug Class] + rhodamine [Drug Class] + lincosamide antibiotic [Drug Class] + cephalosporin [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + macrolide antibiotic [Drug Class] + fosfomycin [Drug Class] + nucleoside antibiotic [Drug Class] + nitroimidazole antibiotic [Drug Class] + rifamycin antibiotic [Drug Class] + peptide antibiotic [Drug Class] + bicyclomycin [Drug Class] + diaminopyrimidine antibiotic [Drug Class] + penam [Drug Class] + benzalkonium chloride [Drug Class] + acridine dye [Drug Class] + isoniazid [Drug Class] + fluoroquinolone antibiotic [Drug Class] |
| Parent Term(s) | 8 ontology terms | Show + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic streptomycin [Antibiotic] + confers_resistance_to_antibiotic kanamycin A [Antibiotic] + confers_resistance_to_antibiotic linezolid [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic trimethoprim [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic florfenicol [Antibiotic] |
| Publications | Floyd JL, et al. 2010. Antimicrob. Agents Chemother. 54(12):5406-12 LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. (PMID 20855745) |
Prevalence of Staphylococcys aureus LmrS among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS |
|---|---|---|---|
| Serratia marcescens | 0% | 0% | 0.23% |
| Staphylococcus aureus | 99.76% | 0% | 99.4% |
| Staphylococcus pseudintermedius | 0% | 0% | 0.51% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 800