streptomycin [Antibiotic]

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Accession ARO:0000040
Synonym(s)streptomycin A sulfate streptomycin sulfate streptomycin sulphate streptomycin A
DefinitionStreptomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Streptomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.
Drug Classaminoglycoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
51 ontology terms | Show
+ APH(3'') [AMR Gene Family] confers_resistance_to_antibiotic
+ APH(6) [AMR Gene Family] confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnEF confers_resistance_to_antibiotic
+ ykkCD confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to streptomycin confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to streptomycin confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to streptomycin confers_resistance_to_antibiotic
+ Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to streptomycin confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis tlyA mutations conferring resistance to aminoglycosides confers_resistance_to_antibiotic
+ aphA15 confers_resistance_to_antibiotic
+ Chlamydomonas reinhardtii 16S rRNA (rrnS) mutation conferring resistance to streptomycin confers_resistance_to_antibiotic
+ Acinetobacter baumannii AbuO confers_resistance_to_antibiotic
+ Escherichia coli mipA confers_resistance_to_antibiotic
+ APH(6)-Id confers_resistance_to_antibiotic
+ APH(3'')-Ib confers_resistance_to_antibiotic
+ aadA2 confers_resistance_to_antibiotic
+ aadA17 confers_resistance_to_antibiotic
+ ANT(6)-Ia confers_resistance_to_antibiotic
+ aadK confers_resistance_to_antibiotic
+ aad(6) confers_resistance_to_antibiotic
+ ANT(6)-Ib confers_resistance_to_antibiotic
+ aadA confers_resistance_to_antibiotic
+ aadA3 confers_resistance_to_antibiotic
+ aadA4 confers_resistance_to_antibiotic
+ aadA5 confers_resistance_to_antibiotic
+ aadA6 confers_resistance_to_antibiotic
+ aadA7 confers_resistance_to_antibiotic
+ aadA8 confers_resistance_to_antibiotic
+ aadA9 confers_resistance_to_antibiotic
+ aadA11 confers_resistance_to_antibiotic
+ aadA12 confers_resistance_to_antibiotic
+ aadA13 confers_resistance_to_antibiotic
+ aadA14 confers_resistance_to_antibiotic
+ aadA15 confers_resistance_to_antibiotic
+ aadA16 confers_resistance_to_antibiotic
+ aadA21 confers_resistance_to_antibiotic
+ aadA22 confers_resistance_to_antibiotic
+ aadA23 confers_resistance_to_antibiotic
+ aadA24 confers_resistance_to_antibiotic
+ aadA25 confers_resistance_to_antibiotic
+ aadA6/aadA10 confers_resistance_to_antibiotic
+ Staphylococcys aureus LmrS confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ aadA27 confers_resistance_to_antibiotic
+ aadS confers_resistance_to_antibiotic
+ aadA10 confers_resistance_to_antibiotic
+ aadA8b confers_resistance_to_antibiotic
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
+ antibiotic sensitive Ribosomal protein S12 (rpsL) targeted_by_antibiotic
Publications

Kotra LP, et al. 2000. Antimicrob Agents Chemother 44(12): 3249-3256. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. (PMID 11083623)

Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)