| Accession | ARO:3003445 |
| Synonym(s) | Rv1694 |
| CARD Short Name | Mtub_tlyA_AMG |
| Definition | Specific mutations that arise in Mycobacterium tuberculosis tlyA resulting in aminoglycosides resistance. |
| AMR Gene Family | Antibiotic resistant tlyA |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Sequence Variants | Mycobacterium tuberculosisg+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + antibiotic target modifying enzyme + ribosomal alteration conferring antibiotic resistance + mutation conferring antibiotic resistance + rRNA methyltransferase conferring antibiotic resistance + antibiotic molecule + 16S ribosomal RNA methyltransferase + antibiotic resistant gene variant or mutant + aminoglycoside antibiotic [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic streptomycin [Antibiotic] + Antibiotic resistant tlyA [AMR Gene Family] + confers_resistance_to_antibiotic capreomycin [Antibiotic] |
| Publications | Maus CE, et al. 2005. Antimicrob Agents Chemother 49(2): 571-577. Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis. (PMID 15673735) Ezewudo M, et al. 2018. Sci Rep 8(1):15382 Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase. (PMID 30337678) |
Prevalence of Mycobacterium tuberculosis tlyA mutations conferring resistance to aminoglycosides among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Mycobacterium tuberculosis | 0.2% | 0% | 0.03% | 0% |
Model Type: protein variant model
Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 450
Legend:
Published Variants:
| PMID: 15673735 | R14W A91E L118P V128E L150P P183L Q184STOP A67E K69E F185L R18STOP Q22STOP N236K E238K R3STOP -nt23:A -nt26:C -nt310:G +nt397:C -nt400:A -nt477:G -nt586:G -nt653:T -nt673:GT -nt758:G |
| PMID: 30337678 | K31fs |
ReSeqTB:
| High Confidence | K31fs |