16S ribosomal RNA methyltransferase

Accession ARO:3000857
DefinitionMethyltransferases that modify the 16S rRNA of the 30S subunit of bacterial ribosomes, conferring resistance to drugs that target 16S rRNA.
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic target alteration
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
4 ontology terms | Show
+ Antibiotic resistant tlyA [AMR Gene Family]
+ antibiotic resistant gidB [AMR Gene Family]
+ 16S rRNA methyltransferase (G1405) [AMR Gene Family]
+ 16S rRNA methyltransferase (A1408) [AMR Gene Family]

Zarubica T, et al. 2011. RNA 17(2): 346-355. The aminoglycoside resistance methyltransferases from the ArmA/Rmt family operate late in the 30S ribosomal biogenesis pathway. (PMID 21177880)

Yokoyama K, et al. 2003. Lancet 362(9399): 1888-1893. Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa. (PMID 14667745)

Galimand M, et al. 2012. Antimicrob Agents Chemother 56(7): 3960-3962. RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family. (PMID 22547620)