16S ribosomal RNA methyltransferase

Accession ARO:3000857
DefinitionMethyltransferases that modify the 16S rRNA of the 30S subunit of bacterial ribosomes, conferring resistance to drugs that target 16S rRNA.
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)1 ontology terms | Show
4 ontology terms | Show
+ Antibiotic resistant tlyA [AMR Gene Family]
+ antibiotic resistant gidB [AMR Gene Family]
+ 16S rRNA methyltransferase (G1405) [AMR Gene Family]
+ 16S rRNA methyltransferase (A1408) [AMR Gene Family]

Zarubica T, et al. 2011. RNA 17(2): 346-355. The aminoglycoside resistance methyltransferases from the ArmA/Rmt family operate late in the 30S ribosomal biogenesis pathway. (PMID 21177880)

Yokoyama K, et al. 2003. Lancet 362(9399): 1888-1893. Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa. (PMID 14667745)

Galimand M, et al. 2012. Antimicrob Agents Chemother 56(7): 3960-3962. RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family. (PMID 22547620)