16S rRNA methyltransferase (A1408) [AMR Gene Family]

Accession ARO:3004272
DefinitionMethyltransferases that methylate the A1408 position of 16S rRNA, which is part of an aminoglycoside binding site.
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic target alteration
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ 16S ribosomal RNA methyltransferase
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
2 ontology terms | Show
+ kamB
+ npmA

Savic M, et al. 2009. Nucleic Acids Res. 37(16):5420-31 Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics. (PMID 19589804)

Wachino J, et al. 2007. Antimicrob Agents Chemother 51(12): 4401-4409. Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides. (PMID 17875999)