Antibiotic resistant tlyA [AMR Gene Family]

Accession ARO:3003443
DefinitiontlyA encodes for hemolysin. It Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Mutation that arise within this gene reduces the binding affinity of aminoglycosides to rRNA.
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic target alteration
Classification9 ontology terms | Show
Parent Term(s)4 ontology terms | Show
1 ontology terms | Show

Maus CE, et al. 2005. Antimicrob Agents Chemother 49(2): 571-577. Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis. (PMID 15673735)