Accession | ARO:3003443 |
Definition | tlyA encodes for hemolysin. It Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Mutation that arise within this gene reduces the binding affinity of aminoglycosides to rRNA. |
Drug Class | aminoglycoside antibiotic |
Resistance Mechanism | antibiotic target alteration |
Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + ribosomal alteration conferring antibiotic resistance + antibiotic target modifying enzyme + antibiotic molecule + mutation conferring antibiotic resistance + rRNA methyltransferase conferring antibiotic resistance |
Parent Term(s) | 4 ontology terms | Show + antibiotic resistant gene variant or mutant + derives_from antibiotic sensitive tlyA + 16S ribosomal RNA methyltransferase + confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class] |
Sub-Term(s) | 1 ontology terms | Show |
Publications | Maus CE, et al. 2005. Antimicrob Agents Chemother 49(2): 571-577. Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis. (PMID 15673735) |