| Accession | ARO:3002626 |
| Synonym(s) | ant6, aadE |
| CARD Short Name | ANT(6)-Ia |
| Definition | ANT(6)-Ia is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and chromosomes in Staphylococcus epidermidis, E. faecium, Streptococcus suis, S. aureus, E. faecalis and Streptococcus mitis. |
| AMR Gene Family | ANT(6) |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Clostridium perfringenswgs, Enterococcus aviumwgs, Enterococcus faecalisg+p+wgs, Enterococcus faeciumg+p+wgs+gi, Enterococcus hiraeg+p+wgs+gi, Erysipelothrix rhusiopathiaeg+gi, Herbinix luporumg+gi, Jeotgalibaca arthritidisg, Klebsiella quasipneumoniaewgs, Lactococcus garvieaep+wgs, Ligilactobacillus animaliswgs, Listeria innocuap+wgs, Macrococcus canisg, Staphylococcus aureusg+p+wgs+gi, Staphylococcus epidermidiswgs, Staphylococcus saprophyticusp+wgs, Streptococcus agalactiaeg+wgs, Streptococcus dysgalactiaeg+wgs, Streptococcus gallolyticusg+wgs, Streptococcus lutetiensiswgs, Streptococcus pasteurianusg+wgs, Streptococcus pyogeneswgs, Streptococcus suisg+wgs+gi, Streptococcus uberiswgs |
| Resistomes with Sequence Variants | Campylobacter jejunigi, Clostridium perfringenswgs, Enterococcus aviumwgs, Enterococcus faecalisg+p+wgs+gi, Enterococcus faeciumg+p+wgs+gi, Enterococcus hiraeg+p+wgs+gi, Erysipelothrix rhusiopathiaeg+gi, Herbinix luporumg+gi, Jeotgalibaca arthritidisg, Klebsiella quasipneumoniaewgs, Lactococcus garvieaep+wgs, Ligilactobacillus animaliswgs, Listeria innocuap+wgs, Macrococcus canisg, Staphylococcus aureusg+p+wgs+gi, Staphylococcus epidermidiswgs, Staphylococcus pseudintermediuswgs, Staphylococcus saprophyticusp+wgs, Streptococcus agalactiaeg+wgs, Streptococcus dysgalactiaeg+wgs, Streptococcus gallolyticusg+wgs, Streptococcus lutetiensiswgs, Streptococcus pasteurianusg+wgs, Streptococcus pyogeneswgs, Streptococcus suisg+wgs+gi, Streptococcus uberiswgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + nucleotidylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside nucleotidyltransferase (ANT) + aminoglycoside antibiotic [Drug Class] + ANT(6) [AMR Gene Family] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Pinto-Alphandary H, et al. 1990. Antimicrob Agents Chemother 34(6): 1294-1296. Emergence of aminoglycoside resistance genes aadA and aadE in the genus Campylobacter. (PMID 2168151) Gill SR, et al. 2005. J Bacteriol 187(7): 2426-2438. Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain. (PMID 15774886) Holden MT, et al. 2009. PLoS One 4(7): E6072. Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis. (PMID 19603075) |
Prevalence of ANT(6)-Ia among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Campylobacter jejuni | 0% | 0% | 0% | 15.38% |
| Clostridium perfringens | 0% | 0% | 0.73% | 0% |
| Enterococcus avium | 0% | 0% | 1.75% | 0% |
| Enterococcus faecalis | 4.55% | 1.23% | 1.35% | 4.17% |
| Enterococcus faecium | 0.32% | 1.68% | 4.99% | 1.96% |
| Enterococcus hirae | 15.38% | 4.76% | 4.17% | 100% |
| Erysipelothrix rhusiopathiae | 27.27% | 0% | 0% | 66.67% |
| Escherichia coli | 0% | 0% | 0% | 0% |
| Herbinix luporum | 100% | 0% | 0% | 100% |
| Jeotgalibaca arthritidis | 100% | 0% | 0% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.13% | 0% |
| Lactococcus garvieae | 0% | 4.17% | 2.22% | 0% |
| Ligilactobacillus animalis | 0% | 0% | 33.33% | 0% |
| Listeria innocua | 0% | 15.79% | 2.26% | 0% |
| Macrococcus canis | 7.14% | 0% | 0% | 0% |
| Staphylococcus aureus | 1.83% | 0.04% | 1.12% | 1.15% |
| Staphylococcus epidermidis | 0% | 0% | 0.08% | 0% |
| Staphylococcus pseudintermedius | 0% | 0% | 0.77% | 0% |
| Staphylococcus saprophyticus | 0% | 2.7% | 0.7% | 0% |
| Streptococcus agalactiae | 5.61% | 0% | 2% | 0% |
| Streptococcus dysgalactiae | 2% | 0% | 2.8% | 0% |
| Streptococcus gallolyticus | 10% | 0% | 9.09% | 0% |
| Streptococcus lutetiensis | 0% | 0% | 2.04% | 0% |
| Streptococcus pasteurianus | 50% | 0% | 20% | 0% |
| Streptococcus pyogenes | 0% | 0% | 0.05% | 0% |
| Streptococcus suis | 17.6% | 0% | 25.34% | 33.33% |
| Streptococcus uberis | 0% | 0% | 6.25% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500