Accession ARO:3007399
DefinitionA family of aminoglycoside 6-O-nucleotidyltransferase enzymes which inactivate streptomycin by catalyzing the transfer of an AMP group from an ATP substrate, thereby conferring resistance to these compounds.
AMR Gene FamilyANT(6)
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification10 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ ANT(6) [AMR Gene Family]
5 ontology terms | Show

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)

Ramirez MS and Tolmasky ME. 2010. Drug Resist Updat 13(6): 151-171. Aminoglycoside modifying enzymes. (PMID 20833577)