| Accession | ARO:3002628 |
| Synonym(s) | aac(6) |
| CARD Short Name | aad(6) |
| Definition | ANT(6)-Ia/aad(6) is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in E. faecalis and Streptococcus oralis. |
| AMR Gene Family | ANT(6) |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Aliarcobacter butzlerig+p+wgs, Anaerostipes hadruswgs, Bacteroides fragiliswgs, Bacteroides thetaiotaomicronwgs, Bifidobacterium breveg+wgs, Bifidobacterium longumg+wgs, Campylobacter colig+wgs, Campylobacter jejuniwgs, Clostridioides difficilegi, Enterocloster clostridioformiswgs, Enterococcus aviumwgs, Enterococcus faecalisg+p+wgs+gi, Enterococcus faeciumg+p+wgs+gi, Enterococcus hiraep+wgs, Erysipelothrix rhusiopathiaeg+gi, Eubacterium limosumwgs, Fusobacterium necrophorumwgs, Lachnospiraceae bacteriumgi, Listeria monocytogeneswgs, Neisseria brasiliensisg+gi, Parabacteroides distasoniswgs, Phocaeicola vulgatuswgs, Roseburia hominisgi, Staphylococcus aureusg+p+wgs+gi, Staphylococcus epidermidisp+wgs, Staphylococcus haemolyticuswgs+gi, Staphylococcus hominiswgs, Staphylococcus pseudintermediusg+wgs+gi, Staphylococcus saprophyticuswgs, Staphylococcus warneriwgs, Streptococcus agalactiaeg+wgs+gi, Streptococcus anginosuswgs, Streptococcus dysgalactiaewgs, Streptococcus equiwgs, Streptococcus gallolyticuswgs, Streptococcus mitisg, Streptococcus mutanswgs, Streptococcus pasteurianusg+wgs+gi, Streptococcus pyogenesg+wgs+gi, Streptococcus suisg+wgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + nucleotidylation of antibiotic conferring resistance + aminoglycoside modifying enzyme + antibiotic molecule + aminoglycoside antibiotic [Drug Class] + aminoglycoside nucleotidyltransferase (ANT) + ANT(6) [AMR Gene Family] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Cerda P, et al. 2007. Int Microbiol 10(1): 57-60. Detection of the aminoglycosidestreptothricin resistance gene cluster ant(6)-sat4-aph(3 ')-III in commensal viridans group streptococci. (PMID 17407061) Schwarz FV, et al. 2001. Plasmid 46(3): 170-187. Sequence of the 50-kb conjugative multiresistance plasmid pRE25 from Enterococcus faecalis RE25. (PMID 11735367) |
Prevalence of aad(6) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Aliarcobacter butzleri | 12.5% | 33.33% | 0.81% | 0% |
| Anaerostipes hadrus | 0% | 0% | 1.72% | 0% |
| Bacteroides fragilis | 0% | 0% | 0.27% | 0% |
| Bacteroides thetaiotaomicron | 0% | 0% | 2.1% | 0% |
| Bifidobacterium breve | 5.88% | 0% | 1.81% | 0% |
| Bifidobacterium longum | 6.32% | 0% | 0.21% | 0% |
| Campylobacter coli | 1.45% | 0% | 0.53% | 0% |
| Campylobacter jejuni | 0% | 0% | 0.23% | 0% |
| Clostridioides difficile | 0% | 0% | 0% | 8.33% |
| Enterocloster clostridioformis | 0% | 0% | 6.98% | 0% |
| Enterococcus avium | 0% | 0% | 3.51% | 0% |
| Enterococcus faecalis | 1.82% | 9.11% | 7.63% | 4.17% |
| Enterococcus faecium | 2.55% | 10.1% | 21.24% | 3.92% |
| Enterococcus hirae | 0% | 7.14% | 1.85% | 0% |
| Erysipelothrix rhusiopathiae | 27.27% | 0% | 0% | 66.67% |
| Eubacterium limosum | 0% | 0% | 25% | 0% |
| Fusobacterium necrophorum | 0% | 0% | 6.98% | 0% |
| Lachnospiraceae bacterium | 0% | 0% | 0% | 33.33% |
| Listeria monocytogenes | 0% | 0% | 0.02% | 0% |
| Neisseria brasiliensis | 100% | 0% | 0% | 50% |
| Parabacteroides distasonis | 0% | 0% | 0.47% | 0% |
| Phocaeicola vulgatus | 0% | 0% | 1.11% | 0% |
| Roseburia hominis | 0% | 0% | 0% | 100% |
| Staphylococcus aureus | 4.89% | 0.11% | 3.17% | 4.87% |
| Staphylococcus epidermidis | 0% | 0.58% | 0.59% | 0% |
| Staphylococcus haemolyticus | 0% | 0% | 0.22% | 20% |
| Staphylococcus hominis | 0% | 0% | 1.46% | 0% |
| Staphylococcus pseudintermedius | 43.33% | 0% | 53.33% | 6.67% |
| Staphylococcus saprophyticus | 0% | 0% | 0.7% | 0% |
| Staphylococcus warneri | 0% | 0% | 1.64% | 0% |
| Streptococcus agalactiae | 7.48% | 0% | 4.57% | 33.33% |
| Streptococcus anginosus | 0% | 0% | 0.58% | 0% |
| Streptococcus dysgalactiae | 0% | 0% | 1.87% | 0% |
| Streptococcus equi | 0% | 0% | 0.23% | 0% |
| Streptococcus gallolyticus | 0% | 0% | 9.09% | 0% |
| Streptococcus mitis | 11.11% | 0% | 0% | 0% |
| Streptococcus mutans | 0% | 0% | 0.39% | 0% |
| Streptococcus pasteurianus | 25% | 0% | 5% | 16.67% |
| Streptococcus pyogenes | 1.12% | 0% | 0.31% | 18.18% |
| Streptococcus suis | 7.2% | 0% | 3.78% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500