| Accession | ARO:3002603 |
| CARD Short Name | aadA3 |
| Definition | aadA3 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids, transposons and integrons in E. coli. |
| AMR Gene Family | ANT(3'') |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Achromobacter xylosoxidanswgs, Acinetobacter baumanniig+p+wgs, Acinetobacter indicusg+p, Acinetobacter juniiwgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiiwgs, Acinetobacter townerig+gi, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilap+wgs, Aeromonas veroniip, Alcaligenes faecalisp, Burkholderia cepaciawgs, Citrobacter freundiiwgs, Citrobacter portucalensisp+wgs, Comamonas testosteronig, Delftia tsuruhatensisg, Enterobacter asburiaep+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniip+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocap, Klebsiella pneumoniaep+wgs+gi, Klebsiella quasipneumoniaep+wgs, Laribacter hongkongensisg+wgs, Morganella morganiig+wgs, Proteus mirabilisg+wgs+gi, Providencia rettgeriwgs, Pseudomonas aeruginosawgs+gi, Pseudomonas monteiliiwgs, Salmonella entericap+wgs+gi, Serratia marcescensp, Shigella flexnerip, Shigella sonneiwgs, Stenotrophomonas maltophiliawgs, Vibrio choleraewgs+gi |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + nucleotidylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside nucleotidyltransferase (ANT) + aminoglycoside antibiotic [Drug Class] + ANT(3'') [AMR Gene Family] + ANT(3'')-I |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic spectinomycin [Antibiotic] + confers_resistance_to_antibiotic streptomycin [Antibiotic] + ANT(3'')-Ia |
| Publications | Parent R and Roy PH. 1992. J Bacteriol 174(9): 2891-2897. The chloramphenicol acetyltransferase gene of Tn2424: a new breed of cat. (PMID 1314803) |
Prevalence of aadA3 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Achromobacter xylosoxidans | 0% | 0% | 0.76% | 0% |
| Acinetobacter baumannii | 0.18% | 0.05% | 0.39% | 0% |
| Acinetobacter indicus | 4.76% | 5.66% | 0% | 0% |
| Acinetobacter junii | 0% | 0% | 1.49% | 0% |
| Acinetobacter nosocomialis | 0% | 0% | 0.57% | 0% |
| Acinetobacter pittii | 0% | 0% | 0.57% | 0% |
| Acinetobacter towneri | 12.5% | 0% | 0% | 100% |
| Aeromonas caviae | 6.82% | 2.6% | 6.45% | 0% |
| Aeromonas hydrophila | 0% | 1.3% | 0.81% | 0% |
| Aeromonas veronii | 0% | 1.54% | 0% | 0% |
| Alcaligenes faecalis | 0% | 20% | 0% | 0% |
| Burkholderia cepacia | 0% | 0% | 3.14% | 0% |
| Citrobacter freundii | 0% | 0% | 3.29% | 0% |
| Citrobacter portucalensis | 0% | 5.88% | 0.9% | 0% |
| Comamonas testosteroni | 20% | 0% | 0% | 0% |
| Delftia tsuruhatensis | 16.67% | 0% | 0% | 0% |
| Enterobacter asburiae | 0% | 0.28% | 5.14% | 0% |
| Enterobacter cloacae | 0% | 0.56% | 4.15% | 0% |
| Enterobacter hormaechei | 0% | 0.77% | 3.71% | 0% |
| Enterobacter kobei | 0% | 1.38% | 5.68% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 5.4% | 0% |
| Escherichia coli | 0.02% | 0.18% | 0.71% | 0% |
| Escherichia fergusonii | 0% | 1.07% | 4.35% | 0% |
| Klebsiella michiganensis | 0% | 1.14% | 1.33% | 0% |
| Klebsiella oxytoca | 0% | 0.68% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0.46% | 1% | 0.95% |
| Klebsiella quasipneumoniae | 0% | 0.21% | 0.66% | 0% |
| Laribacter hongkongensis | 66.67% | 0% | 2.08% | 0% |
| Morganella morganii | 5.77% | 0% | 1.84% | 0% |
| Proteus mirabilis | 2.75% | 0% | 3.3% | 14.81% |
| Providencia rettgeri | 0% | 0% | 0.64% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 1.04% | 2.78% |
| Pseudomonas monteilii | 0% | 0% | 2.38% | 0% |
| Salmonella enterica | 0% | 0.11% | 2.47% | 4.3% |
| Serratia marcescens | 0% | 1.29% | 0% | 0% |
| Shigella flexneri | 0% | 0.8% | 0% | 0% |
| Shigella sonnei | 0% | 0% | 0.07% | 0% |
| Stenotrophomonas maltophilia | 0% | 0% | 0.74% | 0% |
| Vibrio cholerae | 0% | 0% | 0.64% | 4.76% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 450