spectinomycin [Antibiotic]

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Accession ARO:0000039
Synonym(s)Actinospectacin Spectam Togamycin Trobicin
DefinitionSpectinomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Spectinomycin works by binding to the bacterial 30S ribosomal subunit inhibiting translation.
SMILESN/A
PubChem15541
Drug Classaminoglycoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
49 ontology terms | Show
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
+ Borreliella burgdorferi 16S rRNA mutation conferring resistance to spectinomycin confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to spectinomycin confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to spectinomycin confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA (rrsH) mutation conferring resistance to spectinomycin confers_resistance_to_antibiotic
+ Chlamydophila psittaci 16S rRNA mutation conferring resistance to spectinomycin confers_resistance_to_antibiotic
+ Neisseria gonorrhoeae 16S rRNA mutation conferring resistance to spectinomycin confers_resistance_to_antibiotic
+ Neisseria meningitidis 16S rRNA mutation conferring resistance to spectinomycin confers_resistance_to_antibiotic
+ Pasteurella multocida 16S rRNA mutation conferring resistance to spectinomycin confers_resistance_to_antibiotic
+ Salmonella enterica 16S rRNA (rrsD) mutation conferring resistance to spectinomycin confers_resistance_to_antibiotic
+ aadA27 confers_resistance_to_antibiotic
+ ANT(9)-Ia confers_resistance_to_antibiotic
+ spd confers_resistance_to_antibiotic
+ aadA confers_resistance_to_antibiotic
+ aadA2 confers_resistance_to_antibiotic
+ aadA3 confers_resistance_to_antibiotic
+ aadA4 confers_resistance_to_antibiotic
+ aadA5 confers_resistance_to_antibiotic
+ aadA6 confers_resistance_to_antibiotic
+ aadA7 confers_resistance_to_antibiotic
+ aadA8 confers_resistance_to_antibiotic
+ aadA9 confers_resistance_to_antibiotic
+ aadA11 confers_resistance_to_antibiotic
+ aadA12 confers_resistance_to_antibiotic
+ aadA13 confers_resistance_to_antibiotic
+ aadA14 confers_resistance_to_antibiotic
+ aadA15 confers_resistance_to_antibiotic
+ aadA16 confers_resistance_to_antibiotic
+ aadA17 confers_resistance_to_antibiotic
+ aadA21 confers_resistance_to_antibiotic
+ aadA22 confers_resistance_to_antibiotic
+ aadA23 confers_resistance_to_antibiotic
+ aadA24 confers_resistance_to_antibiotic
+ aadA25 confers_resistance_to_antibiotic
+ aadA6/aadA10 confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ aadA10 confers_resistance_to_antibiotic
+ aadA8b confers_resistance_to_antibiotic
+ ANT(3'')-Ib confers_resistance_to_antibiotic
+ ANT(3'')-IIa confers_resistance_to_antibiotic
+ ANT(3'')-IIb confers_resistance_to_antibiotic
+ ANT(3'')-IIc confers_resistance_to_antibiotic
+ APH(9)-Ib confers_resistance_to_antibiotic
+ ANT(3'')-II-AAC(6')-IId bifunctional protein confers_resistance_to_antibiotic
+ APH(9)-Ia confers_resistance_to_antibiotic
+ ANT(9)-Ib confers_resistance_to_antibiotic
+ ANT(9)-Ic confers_resistance_to_antibiotic
+ Bacillus subtilis rpsE mutations conferring resistance to spectinomycin confers_resistance_to_antibiotic
+ APH(9)-Ic confers_resistance_to_antibiotic
Publications

Kotra LP, et al. 2000. Antimicrob Agents Chemother 44(12): 3249-3256. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. (PMID 11083623)

Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)
Curator Acknowledgements
Curator Description Most Recent Edit