Accession ARO:3002607
CARD Short NameaadA7
DefinitionaadA7 is an integron-encoded aminoglycoside nucleotidyltransferase gene in V. fluvialis, P. aeruginosa, E. coli, V. cholerae and S. enterica.
AMR Gene FamilyANT(3'')
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsCitrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Escherichia colip+wgs, Morganella morganiiwgs, Proteus mirabiliswgs, Pseudomonas aeruginosag+p+wgs, Salmonella entericag+p+wgs+gi, Vibrio choleraewgs
Classification12 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ ANT(3'')-Ia
+ confers_resistance_to_antibiotic spectinomycin [Antibiotic]
+ confers_resistance_to_antibiotic streptomycin [Antibiotic]

Ahmed AM, et al. 2004. J Antimicrob Chemother 53(6): 947-951. New aminoglycoside acetyltransferase gene, aac(3)-Id, in a class 1 integron from a multiresistant strain of Vibrio fluvialis isolated from an infant aged 6 months. (PMID 15117923)


Prevalence of aadA7 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Citrobacter portucalensis0%0%0.9%0%
Citrobacter werkmanii0%0%2.56%0%
Escherichia coli0%0.01%0.1%0%
Morganella morganii0%0%0.61%0%
Proteus mirabilis0%0%0.17%0%
Pseudomonas aeruginosa1.07%0.29%0.9%0%
Salmonella enterica1.26%0.22%0.65%0.33%
Vibrio cholerae0%0%0.06%0%
Show Perfect Only

Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 450

>gb|BAD00739.1|+|aadA7 [Vibrio fluvialis]

>gb|AB114632.1|+|656-1453|aadA7 [Vibrio fluvialis]