| Accession | ARO:3000755 |
| Definition | The 16S rRNA of the 30S ribosomal subunit helps to stabilize the aminoacyl-tRNAs for pairing with the mRNA codons. Some antibiotics (aminoglycosides) that target the 16S rRNA lead to mRNA misreading as well as premature termination. Other antibiotics (tetracyclines) that target the 16S rRNA prevent incoming charged-tRNAs from binding to the ribosome's A-site, stopping elongation. |
| Drug Class | aminoglycoside antibiotic, tetracycline antibiotic |
| Classification | 4 ontology terms | Show |
| Parent Term(s) | 36 ontology terms | Show + targeted_by_antibiotic astromicin [Antibiotic] + targeted_by_antibiotic neomycin [Antibiotic] + targeted_by_antibiotic dibekacin [Antibiotic] + targeted_by_antibiotic streptothricin [Antibiotic] + targeted_by_antibiotic amikacin [Antibiotic] + targeted_by_antibiotic gentamicin C [Antibiotic] + targeted_by aminoglycoside antibiotic [Drug Class] + targeted_by_antibiotic ribostamycin [Antibiotic] + targeted_by_antibiotic butirosin [Antibiotic] + targeted_by_antibiotic tigecycline [Antibiotic] + targeted_by_antibiotic sisomicin [Antibiotic] + targeted_by_antibiotic apramycin [Antibiotic] + targeted_by_antibiotic netilmicin [Antibiotic] + targeted_by_antibiotic spectinomycin [Antibiotic] + targeted_by_antibiotic streptomycin [Antibiotic] + targeted_by_antibiotic kanamycin A [Antibiotic] + targeted_by_antibiotic tetracycline [Antibiotic] + targeted_by_antibiotic tobramycin [Antibiotic] + targeted_by_antibiotic doxycycline [Antibiotic] + targeted_by tetracycline antibiotic [Drug Class] + targeted_by_antibiotic edeine + targeted_by_antibiotic minocycline [Antibiotic] + targeted_by_antibiotic hygromycin B [Antibiotic] + targeted_by_antibiotic chlortetracycline [Antibiotic] + targeted_by_antibiotic isepamicin [Antibiotic] + targeted_by_antibiotic G418 [Antibiotic] + targeted_by_antibiotic arbekacin [Antibiotic] + targeted_by_antibiotic gentamicin B [Antibiotic] + targeted_by_antibiotic paromomycin [Antibiotic] + targeted_by_antibiotic lividomycin [Antibiotic] + targeted_by_antibiotic demeclocycline [Antibiotic] + targeted_by_antibiotic oxytetracycline [Antibiotic] + targeted_by_antibiotic lividomycin A [Antibiotic] + targeted_by_antibiotic lividomycin B [Antibiotic] + part_of 30S ribosomal subunit + ribonucleic acid |
| Sub-Term(s) | 14 ontology terms | Show + 16S rRNA with mutation conferring antibiotic resistance derives_from + Antibiotic sensitive Escherichia coli 16S rRNA + Antibiotic sensitive Mycobacteroides abscessus 16S rRNA + Antibiotic sensitive Borreliella burgdorferi 16S rRNA + Antibiotic sensitive Chlamydophila psittaci 16S rRNA + Antibiotic sensitive Helicobacter pylori 16S rRNA + Antibiotic sensitive Mycobacteroides chelonae 16S rRNA + Antibiotic sensitive Mycolicibacterium smegmatis 16S rRNA + Antibiotic sensitive Neisseria gonorrhoeae 16S rRNA + Antibiotic sensitive Neisseria meningitidis 16S rRNA + Antibiotic sensitive Pasteurella multocida 16S rRNA + Antibiotic sensitive Cutibacterium acnes 16S rRNA + Antibiotic sensitive Salmonella enterica serovar Typhimurium 16S rRNA + Antibiotic sensitive Mycobacterium tuberculosis 16S rRNA |
| Publications | Wong CH, et al. 1998. Chem Biol 5(7): 397-406. Specificity of aminoglycoside antibiotics for the A-site of the decoding region of ribosomal RNA. (PMID 9662506) |