Accession ARO:3000119
DefinitionEdeines are basic linear peptides produced by Bacillus brevis Vm4. They have antibacterial as well as antifungal, antiviral, and anticancer properties. Edeines are bacteriostatic and bacteriocidal at low and high concentrations, respectively. They are able to inhibit DNA synthesis and protein translation. These compounds are synthesized by nonribosomal peptide synthetases and contain numerous unusual amino acids.
Drug Classpeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ peptide antibiotic [Drug Class]
6 ontology terms | Show
+ edeine A [Antibiotic]
+ edeine B [Antibiotic]
+ edeine D [Antibiotic]
+ edeine F [Antibiotic]
+ 30S ribosomal subunit P-site targeted_by
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic

Katz E and Demain AL. 1977. Bacteriol Rev 41(2): 449-474. The peptide antibiotics of Bacillus: chemistry, biogenesis, and possible functions. (PMID 70202)