edeine A [Antibiotic]

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Accession ARO:3000130
DefinitionEdeine A is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and spermidine. Edeine A is a mixture of edeine A1 and its inactive isomer, edeine A2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication.
Drug Classpeptide antibiotic
Classification3 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ peptide antibiotic [Drug Class]
+ edeine
Sub-Term(s)
3 ontology terms | Show
+ 30S ribosomal subunit P-site targeted_by_antibiotic
+ Edeine acetyltransferase [AMR Gene Family] confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA mutation conferring resistance to edeine confers_resistance_to_antibiotic
Publications

Hettinger TP and Craig LC. 1970. Biochemistry 9(5): 1224-1232. Edeine. IV. Structures of the antibiotic peptides edeines A1 and B1. (PMID 4984939)

Katz E and Demain AL. 1977. Bacteriol Rev 41(2): 449-474. The peptide antibiotics of Bacillus: chemistry, biogenesis, and possible functions. (PMID 70202)

Dinos G, et al. 2004. Mol Cell 13(1): 113-124. Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding. (PMID 14731399)