| Accession | ARO:3000130 |
| Definition | Edeine A is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and spermidine. Edeine A is a mixture of edeine A1 and its inactive isomer, edeine A2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. |
| Drug Class | peptide antibiotic |
| Classification | 3 ontology terms | Show |
| Parent Term(s) | 2 ontology terms | Show |
| Sub-Term(s) | 4 ontology terms | Show + 30S ribosomal subunit P-site targeted_by_antibiotic + Edeine acetyltransferase [AMR Gene Family] confers_resistance_to_antibiotic + Escherichia coli 16S rRNA mutation conferring resistance to edeine confers_resistance_to_antibiotic + EdeQ confers_resistance_to_antibiotic |
| Publications | Hettinger TP and Craig LC. 1970. Biochemistry 9(5): 1224-1232. Edeine. IV. Structures of the antibiotic peptides edeines A1 and B1. (PMID 4984939) Katz E and Demain AL. 1977. Bacteriol Rev 41(2): 449-474. The peptide antibiotics of Bacillus: chemistry, biogenesis, and possible functions. (PMID 70202) Dinos G, et al. 2004. Mol Cell 13(1): 113-124. Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding. (PMID 14731399) |
