Accession ARO:3004063
CARD Short NameEdeQ
DefinitionEdeQ is an N-acetyltransferase enzyme that confers high-level self-resistance to edeine in Brevibacillus brevis, a natural edeine producer. EdeQ converts active edeine to N-acetyledeine, which is ineffective in vivo.
AMR Gene FamilyEdeine acetyltransferase
Drug Classpeptide antibiotic, polyamine antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesBrevibacillus breviswgs
Resistomes with Sequence VariantsBrevibacillus brevisg+wgs
Classification14 ontology terms | Show
Parent Term(s)6 ontology terms | Show
+ Edeine acetyltransferase [AMR Gene Family]
+ gene involved in self-resistance to antibiotic
+ confers_resistance_to_antibiotic edeine A [Antibiotic]
+ confers_resistance_to_antibiotic edeine B [Antibiotic]
+ confers_resistance_to_antibiotic edeine D [Antibiotic]
+ confers_resistance_to_antibiotic edeine F [Antibiotic]

Westman EL, et al. 2013. Chem. Biol. 20(8):983-90 Self resistance to the atypical cationic antimicrobial peptide edeine of Brevibacillus brevis Vm4 by the N-acetyltransferase EdeQ. (PMID 23891151)


Prevalence of EdeQ among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Brevibacillus brevis100%0%100%0%
Show Perfect Only

Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 250

>gb|AHH86051.1|+|EdeQ [Brevibacillus brevis]

>gb|KC771276.1|+|44895-45332|EdeQ [Brevibacillus brevis]