edeine B [Antibiotic]

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Accession ARO:3000134
DefinitionEdeine B is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and guanylspermidine. Edeine B is a mixture of edeine B1 and its inactive isomer, edeine B2. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. Edeine B has also been shown to inhibit septation and cause filamentous morphology, also leading to cell death.
Drug Classpeptide antibiotic
Classification3 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ peptide antibiotic [Drug Class]
+ edeine
Sub-Term(s)
3 ontology terms | Show
+ 30S ribosomal subunit P-site targeted_by_antibiotic
+ Edeine acetyltransferase [AMR Gene Family] confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA mutation conferring resistance to edeine confers_resistance_to_antibiotic
Publications

Hettinger TP and Craig LC. 1970. Biochemistry 9(5): 1224-1232. Edeine. IV. Structures of the antibiotic peptides edeines A1 and B1. (PMID 4984939)

Katz E and Demain AL. 1977. Bacteriol Rev 41(2): 449-474. The peptide antibiotics of Bacillus: chemistry, biogenesis, and possible functions. (PMID 70202)

Shimotohno KW, et al. 2010. Biol Pharm Bull 33(4): 568-571. Inhibition of septation in Bacillus subtilis by a peptide antibiotic, edeine B(1). (PMID 20410587)