Edeine acetyltransferase [AMR Gene Family]

Accession ARO:3004064
DefinitionEdeine acetyltransferase enzymes catalyze the transfer of an acetyl group to active edeine, converting it to an inactive form in vivo. This mechanism is used for high-level self-resistance in edeine-producing Brevibacillus spp.
Drug Classpeptide antibiotic, polyamine antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)9 ontology terms | Show
+ participates_in acylation of antibiotic conferring resistance
+ confers_resistance_to_antibiotic edeine A [Antibiotic]
+ confers_resistance_to_antibiotic edeine B [Antibiotic]
+ confers_resistance_to_antibiotic edeine D [Antibiotic]
+ confers_resistance_to_antibiotic edeine F [Antibiotic]
+ confers_resistance_to_drug_class polyamine antibiotic [Drug Class]
+ antibiotic inactivation enzyme
+ determinant of resistance to peptide antibiotics
+ determinant of resistance to polyamine antibiotics
Sub-Term(s)
1 ontology terms | Show
+ EdeQ
Publications

Westman EL, et al. 2013. Chem. Biol. 20(8):983-90 Self resistance to the atypical cationic antimicrobial peptide edeine of Brevibacillus brevis Vm4 by the N-acetyltransferase EdeQ. (PMID 23891151)