edeine D [Antibiotic]

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Accession ARO:3000135
DefinitionEdeine D is a subtype of edeine similar to edeine A with the beta-tyr replaced by beta-phe-beta-ala. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication.
Drug Classpeptide antibiotic
Classification3 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ edeine
+ peptide antibiotic [Drug Class]
4 ontology terms | Show
+ 30S ribosomal subunit P-site targeted_by_antibiotic
+ Edeine acetyltransferase [AMR Gene Family] confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA mutation conferring resistance to edeine confers_resistance_to_antibiotic
+ EdeQ confers_resistance_to_antibiotic

Katz E and Demain AL. 1977. Bacteriol Rev 41(2): 449-474. The peptide antibiotics of Bacillus: chemistry, biogenesis, and possible functions. (PMID 70202)