Ontology | CARD's Antibiotic Resistance Ontology |
Accession | ARO:3000136 |
Definition | Edeine F is a subtype of edeine similar to edeine B with beta-tyr replaced by beta-phe-beta-ala. Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. |
SMILES | N/A |
PubChem | 194407 |
Drug Class | peptide antibiotic |
Classification | 3 ontology terms | Show |
Parent Term(s) | 2 ontology terms | Show |
Sub-Term(s) | 4 ontology terms | Show + 30S ribosomal subunit P-site targeted_by_antibiotic + Edeine acetyltransferase [AMR Gene Family] confers_resistance_to_antibiotic + Escherichia coli 16S rRNA mutation conferring resistance to edeine confers_resistance_to_antibiotic + EdeQ confers_resistance_to_antibiotic |
Publications | Wojciechowska H, et al. 1983. J Antibiot (Tokyo) 36(7): 793-798. The antibiotic edeine. XII. Isolation and structure of edeine F. (PMID 6615592) |
Curator | Description | Most Recent Edit |
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