hygromycin B [Antibiotic]

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Accession ARO:3000214
DefinitionHygromycin B is an aminoglycoside antibiotic used to treat different types of bacterial infections. Hygromycin B works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Hygromycin B has also been shown to interact with eukaryotic cells.
Drug Classaminoglycoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
5 ontology terms | Show
+ APH(4) [AMR Gene Family] confers_resistance_to_antibiotic
+ APH(7'') [AMR Gene Family] confers_resistance_to_antibiotic
+ Mycolicibacterium smegmatis 16S rRNA (rrsA) mutation conferring resistance to hygromycin B confers_resistance_to_antibiotic
+ Mycolicibacterium smegmatis 16S rRNA (rrsB) mutation conferring resistance to hygromycin B confers_resistance_to_antibiotic
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
Publications

Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173)

Brodersen DE, et al. 2000. Cell 103(7): 1143-1154. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. (PMID 11163189)