sisomicin [Antibiotic]

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Accession ARO:0000035
Synonym(s)antibiotic 6640 dehydrogentamicin rickamicin sisomycin sissomicin
DefinitionSisomicin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Sisomicin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.
Drug Classaminoglycoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
64 ontology terms | Show
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
+ armA confers_resistance_to_antibiotic
+ rmtA confers_resistance_to_antibiotic
+ rmtB confers_resistance_to_antibiotic
+ rmtC confers_resistance_to_antibiotic
+ sgm confers_resistance_to_antibiotic
+ AAC(3)-Ia confers_resistance_to_antibiotic
+ AAC(3)-Id confers_resistance_to_antibiotic
+ AAC(3)-Ic confers_resistance_to_antibiotic
+ APH(2'')-If confers_resistance_to_antibiotic
+ AAC(6')-31 confers_resistance_to_antibiotic
+ AAC(3)-Ib confers_resistance_to_antibiotic
+ AAC(3)-IIg confers_resistance_to_antibiotic
+ AAC(3)-IId confers_resistance_to_antibiotic
+ AAC(3)-IIe confers_resistance_to_antibiotic
+ AAC(3)-IIc confers_resistance_to_antibiotic
+ AAC(3)-IIb confers_resistance_to_antibiotic
+ AAC(3)-IIa confers_resistance_to_antibiotic
+ AAC(3)-IIIa confers_resistance_to_antibiotic
+ AAC(3)-IIIb confers_resistance_to_antibiotic
+ AAC(3)-IVa confers_resistance_to_antibiotic
+ AAC(3)-VIa confers_resistance_to_antibiotic
+ AAC(6')-If confers_resistance_to_antibiotic
+ AAC(6')-Ig confers_resistance_to_antibiotic
+ AAC(6')-Ih confers_resistance_to_antibiotic
+ AAC(6')-Ii confers_resistance_to_antibiotic
+ AAC(6')-Ij confers_resistance_to_antibiotic
+ AAC(6')-Ik confers_resistance_to_antibiotic
+ AAC(6')-Ip confers_resistance_to_antibiotic
+ AAC(6')-Iq confers_resistance_to_antibiotic
+ AAC(6')-Ir confers_resistance_to_antibiotic
+ AAC(6')-Is confers_resistance_to_antibiotic
+ AAC(6')-Isa confers_resistance_to_antibiotic
+ AAC(6')-It confers_resistance_to_antibiotic
+ AAC(6')-Iu confers_resistance_to_antibiotic
+ AAC(6')-Iv confers_resistance_to_antibiotic
+ AAC(6')-Iw confers_resistance_to_antibiotic
+ AAC(6')-Ix confers_resistance_to_antibiotic
+ AAC(6')-Iy confers_resistance_to_antibiotic
+ AAC(6')-Iz confers_resistance_to_antibiotic
+ AAC(6')-Iaa confers_resistance_to_antibiotic
+ AAC(6')-Iad confers_resistance_to_antibiotic
+ AAC(6')-Iae confers_resistance_to_antibiotic
+ AAC(6')-Iaf confers_resistance_to_antibiotic
+ AAC(6')-Iai confers_resistance_to_antibiotic
+ AAC(6')-Ia confers_resistance_to_antibiotic
+ AAC(6')-Ic confers_resistance_to_antibiotic
+ AAC(6')-Iak confers_resistance_to_antibiotic
+ AAC(6')-Ian confers_resistance_to_antibiotic
+ AAC(6')-Iaj confers_resistance_to_antibiotic
+ AAC(6')-Im confers_resistance_to_antibiotic
+ AAC(6')-Il confers_resistance_to_antibiotic
+ AAC(6')-I-48 confers_resistance_to_antibiotic
+ AAC(6')-Iap confers_resistance_to_antibiotic
+ AAC(6')-IIa confers_resistance_to_antibiotic
+ AAC(6')-IIb confers_resistance_to_antibiotic
+ AAC(6')-IIc confers_resistance_to_antibiotic
+ ANT(2'')-Ia confers_resistance_to_antibiotic
+ AAC(6')-Iih confers_resistance_to_antibiotic
+ AAC(6')-Iid confers_resistance_to_antibiotic
+ AAC(3)-Ib/AAC(6')-Ib3 bifunctional protein confers_resistance_to_antibiotic
+ AAC(6')-Ie-APH(2'')-Ia bifunctional protein confers_resistance_to_antibiotic
+ ANT(3'')-II-AAC(6')-IId bifunctional protein confers_resistance_to_antibiotic
+ AAC(6')-I30 confers_resistance_to_antibiotic
Publications

Kotra LP, et al. 2000. Antimicrob Agents Chemother 44(12): 3249-3256. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. (PMID 11083623)

Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)