| Accession | ARO:3002528 |
| Synonym(s) | AAC(3)-Ia C aacC1 aacC-A1 |
| CARD Short Name | AAC(3)-Ia |
| Definition | AAC(3)-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in S. marcescens, E. coli, Acinetobacter baumannii, Klebsiella pneumoniae, Klebsiella oxytoca, P. aeruginosa, Salmonella typhimurium and Proteus mirabilis. |
| AMR Gene Family | AAC(3) |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+wgs+gi, Brucella abortuswgs, Citrobacter freundiip+wgs, Enterobacter asburiaewgs, Enterobacter cloacaep, Enterobacter hormaecheiwgs, Escherichia colig+wgs, Helicobacter pylorig, Klebsiella aerogenesg+gi, Klebsiella michiganensiswgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Morganella morganiiwgs, Proteus mirabilisg+wgs, Pseudomonas aeruginosawgs, Pseudomonas monteiliiwgs, Pseudomonas putidawgs, Salmonella entericawgs, Serratia marcescensg+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + acylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + AAC(3) [AMR Gene Family] + antibiotic mixture |
| Parent Term(s) | 4 ontology terms | Show + confers_resistance_to_antibiotic sisomicin [Antibiotic] + confers_resistance_to_antibiotic gentamicin [Antibiotic] + confers_resistance_to_antibiotic astromicin [Antibiotic] + AAC(3)-I |
| Publications | Wohlleben W, et al. 1989. Mol Gen Genet 217(2-3): 202-208. On the evolution of Tn21-like multiresistance transposons: sequence analysis of the gene (aacC1) for gentamicin acetyltransferase-3-I(AAC(3)-I), another member of the Tn21-based expression cassette. (PMID 2549372) Javier Teran F, et al. 1991. J Antimicrob Chemother 28(3): 333-346. Characterization of two aminoglycoside-(3)-N-acetyltransferase genes and assay as epidemiological probes. (PMID 1960117) |
Prevalence of AAC(3)-Ia among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 16.99% | 0% | 13.74% | 7.55% |
| Brucella abortus | 0% | 0% | 0.5% | 0% |
| Citrobacter freundii | 0% | 0.31% | 0.19% | 0% |
| Enterobacter asburiae | 0% | 0% | 0.79% | 0% |
| Enterobacter cloacae | 0% | 0.56% | 0% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.26% | 0% |
| Escherichia coli | 0.05% | 0% | 0.01% | 0% |
| Helicobacter pylori | 0.77% | 0% | 0% | 0% |
| Klebsiella aerogenes | 4% | 0% | 0% | 25% |
| Klebsiella michiganensis | 0% | 0% | 0.27% | 0% |
| Klebsiella oxytoca | 0% | 0% | 0.42% | 0% |
| Klebsiella pneumoniae | 0% | 0.03% | 0.12% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.21% | 0.26% | 0% |
| Morganella morganii | 0% | 0% | 0.61% | 0% |
| Proteus mirabilis | 0.92% | 0% | 0.33% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.43% | 0% |
| Pseudomonas monteilii | 0% | 0% | 2.38% | 0% |
| Pseudomonas putida | 0% | 0% | 0.53% | 0% |
| Salmonella enterica | 0% | 0% | 0.05% | 0% |
| Serratia marcescens | 1.52% | 0% | 1.05% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300