AAC(3) [AMR Gene Family]

Accession ARO:3000322
DefinitionA category of aminoglycoside N-acetyltransferase enzymes with modification regiospecificity based at the 3-amino group of the respective antibiotic. These enzymes inactivate aminoglycoside antibiotics through acetylation of the 3-amino group of the compound.
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ aminoglycoside acetyltransferase (AAC)
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
9 ontology terms | Show

Dubois V, et al. 2008. J Antimicrob Chemother 62(2): 316-323. Beta-lactam and aminoglycoside resistance rates and mechanisms among Pseudomonas aeruginosa in French general practice (community and private healthcare centres). (PMID 18467306)

Allmansberger R, et al. 1985. Mol Gen Genet 198(3): 514-520. Genes for gentamicin-(3)-N-acetyl-transferases III and IV. II. Nucleotide sequences of three AAC(3)-III genes and evolutionary aspects. (PMID 3892230)

Vliegenthart JS, et al. 1991. Antimicrob Agents Chemother 35(5): 892-897. Nucleotide sequence of the aacC3 gene, a gentamicin resistance determinant encoding aminoglycoside-(3)-N-acetyltransferase III expressed in Pseudomonas aeruginosa but not in Escherichia coli. (PMID 1649572)

Schwocho LR, et al. 1995. Antimicrob Agents Chemother 39(8): 1790-1796. Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ib, from Pseudomonas aeruginosa. (PMID 7486920)

Doublet B, et al. 2004. Antimicrob Agents Chemother 48(10): 3806-3812. Variant Salmonella genomic island 1 antibiotic resistance gene cluster containing a novel 3'-N-aminoglycoside acetyltransferase gene cassette, aac(3)-Id, in Salmonella enterica serovar newport. (PMID 15388438)

Rather PN, et al. 1993. Antimicrob Agents Chemother 37(10): 2074-2079. Analysis of the aac(3)-VIa gene encoding a novel 3-N-acetyltransferase. (PMID 8257126)

Gionechetti F, et al. 2008. Microb Drug Resist 14(2): 93-99. Characterization of antimicrobial resistance and class 1 integrons in Enterobacteriaceae isolated from Mediterranean herring gulls (Larus cachinnans). (PMID 18476779)

Heuer H, et al. 2002. FEMS Microbiol Ecol 42(2): 289-302. Gentamicin resistance genes in environmental bacteria: prevalence and transfer. (PMID 19709289)

Brau B, et al. 1984. Mol Gen Genet 193(1): 179-187. Genes for gentamicin-(3)-N-acetyltransferases III and IV: I. Nucleotide sequence of the AAC(3)-IV gene and possible involvement of an IS140 element in its expression. (PMID 6318050)

Lopez-Cabrera M, et al. 1989. J Bacteriol 171(1): 321-328. Isolation and nucleotide sequencing of an aminocyclitol acetyltransferase gene from Streptomyces rimosus forma paromomycinus. (PMID 2914849)

Riccio ML, et al. 2003. Antimicrob Agents Chemother 47(5): 1746-1748. Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron. (PMID 12709352)

Wohlleben W, et al. 1989. Mol Gen Genet 217(2-3): 202-208. On the evolution of Tn21-like multiresistance transposons: sequence analysis of the gene (aacC1) for gentamicin acetyltransferase-3-I(AAC(3)-I), another member of the Tn21-based expression cassette. (PMID 2549372)

Levings RS, et al. 2005. Antimicrob Agents Chemother 49(3): 1238-1241. New integron-associated gene cassette encoding a 3-N-aminoglycoside acetyltransferase. (PMID 15728939)

Salauze D, et al. 1991. Gene 101(1): 143-148. Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae. (PMID 2060791)

Rather PN, et al. 1992. J Bacteriol 174(10): 3196-3203. Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins. (PMID 1577689)

Call DR, et al. 2010. Antimicrob Agents Chemother 54(2): 590-596. blaCMY-2-positive IncA/C plasmids from Escherichia coli and Salmonella enterica are a distinct component of a larger lineage of plasmids. (PMID 19949054)

Ishikawa J, et al. 2000. Antimicrob Agents Chemother 44(2): 437-440. Identification and characterization of the point mutation which affects the transcription level of the chromosomal 3-N-acetyltransferase gene of Streptomyces griseus SS-1198. (PMID 10639379)