| Accession | ARO:3004623 |
| Synonym(s) | aacC2d |
| CARD Short Name | AAC(3)-IId |
| Definition | AAC(3)-IId is a plasmid-encoded aminoglycoside acetyltransferase in E. coli. |
| AMR Gene Family | AAC(3) |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniip+wgs, Acinetobacter indicusg+p+wgs, Acinetobacter johnsoniip+wgs, Acinetobacter juniip+wgs, Acinetobacter lwoffiiwgs, Acinetobacter nosocomialisp+wgs, Acinetobacter pittiip+wgs, Acinetobacter radioresistenswgs, Acinetobacter towneriwgs, Acinetobacter wuhouensisp+wgs, Actinobacillus indolicusg, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilag+p+wgs, Aeromonas veroniig+wgs, Burkholderia cenocepaciawgs, Burkholderia multivoranswgs, Citrobacter amalonaticusp+wgs, Citrobacter freundiig+p+wgs, Citrobacter koserig+p+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Cronobacter malonaticuswgs, Enterobacter asburiaep+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia albertiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniip+wgs, Glaesserella parasuisg+wgs, Klebsiella aerogenesg+p+wgs, Klebsiella huaxiensisg, Klebsiella michiganensisg+p+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatawgs, Morganella morganiig+wgs, Proteus mirabilisg+p+wgs, Proteus vulgariswgs, Providencia rettgerig+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosag+p+wgs, Pseudomonas putidag+p, Raoultella planticolap+wgs, Salmonella entericag+p+wgs, Serratia marcescensg+p+wgs, Shigella boydiiwgs, Shigella flexnerig+p+wgs, Shigella sonneig+wgs, Stenotrophomonas maltophiliawgs, Vibrio choleraep+wgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniip+wgs, Acinetobacter indicusg+p+wgs, Acinetobacter johnsoniip+wgs, Acinetobacter juniip+wgs, Acinetobacter lwoffiiwgs, Acinetobacter nosocomialisp+wgs, Acinetobacter pittiip+wgs, Acinetobacter radioresistenswgs, Acinetobacter towneriwgs, Acinetobacter wuhouensisp+wgs, Actinobacillus indolicusg, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilag+p+wgs, Aeromonas veroniig+wgs, Burkholderia cenocepaciawgs, Burkholderia multivoranswgs, Citrobacter amalonaticusp+wgs, Citrobacter freundiig+p+wgs, Citrobacter koserig+p+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Cronobacter malonaticuswgs, Enterobacter asburiaep+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia albertiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniip+wgs, Glaesserella parasuisg+wgs, Klebsiella aerogenesg+p+wgs, Klebsiella huaxiensisg, Klebsiella michiganensisg+p+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatawgs, Morganella morganiig+wgs, Proteus mirabilisg+p+wgs, Proteus vulgarisp+wgs, Providencia rettgerig+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosag+p+wgs, Pseudomonas putidag+p, Raoultella planticolap+wgs, Salmonella entericag+p+wgs, Serratia marcescensg+p+wgs, Shigella boydiiwgs, Shigella flexnerig+p+wgs, Shigella sonneig+wgs, Stenotrophomonas maltophiliawgs, Vibrio choleraep+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + aminoglycoside modifying enzyme + acylation of antibiotic conferring resistance + antibiotic molecule + aminoglycoside acetyltransferase (AAC) + aminoglycoside antibiotic [Drug Class] + antibiotic mixture + AAC(3) [AMR Gene Family] |
| Parent Term(s) | 8 ontology terms | Show + confers_resistance_to_antibiotic dibekacin [Antibiotic] + confers_resistance_to_antibiotic sisomicin [Antibiotic] + confers_resistance_to_antibiotic netilmicin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic 6'-N-ethylnetilmicin [Antibiotic] + confers_resistance_to_antibiotic 2'-N-ethylnetilmicin [Antibiotic] + confers_resistance_to_antibiotic gentamicin [Antibiotic] + AAC(3)-II |
| Publications | Ho PL, et al. 2010. J. Med. Microbiol. 59(Pt 6):702-7 Genetic identity of aminoglycoside-resistance genes in Escherichia coli isolates from human and animal sources. (PMID 20185552) |
Prevalence of AAC(3)-IId among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0.52% | 0.91% | 0% |
| Acinetobacter indicus | 9.52% | 13.21% | 3.9% | 0% |
| Acinetobacter johnsonii | 0% | 1.39% | 5.45% | 0% |
| Acinetobacter junii | 0% | 16.67% | 1.49% | 0% |
| Acinetobacter lwoffii | 0% | 0% | 2.63% | 0% |
| Acinetobacter nosocomialis | 0% | 1.64% | 2.87% | 0% |
| Acinetobacter pittii | 0% | 2.96% | 5.97% | 0% |
| Acinetobacter radioresistens | 0% | 0% | 1.75% | 0% |
| Acinetobacter towneri | 0% | 0% | 7.69% | 0% |
| Acinetobacter wuhouensis | 0% | 4.55% | 50% | 0% |
| Actinobacillus indolicus | 100% | 0% | 0% | 0% |
| Aeromonas caviae | 2.27% | 2.6% | 3.76% | 0% |
| Aeromonas hydrophila | 4.62% | 2.6% | 1.61% | 0% |
| Aeromonas veronii | 3.64% | 0% | 1.12% | 0% |
| Burkholderia cenocepacia | 0% | 0% | 0.44% | 0% |
| Burkholderia multivorans | 0% | 0% | 0.24% | 0% |
| Citrobacter amalonaticus | 0% | 8.33% | 5.45% | 0% |
| Citrobacter freundii | 1.64% | 8.92% | 11.03% | 0% |
| Citrobacter koseri | 6.25% | 15% | 3.6% | 0% |
| Citrobacter portucalensis | 0% | 14.71% | 17.12% | 0% |
| Citrobacter werkmanii | 0% | 0% | 10.26% | 0% |
| Cronobacter malonaticus | 0% | 0% | 1.82% | 0% |
| Enterobacter asburiae | 0% | 0.55% | 0.79% | 0% |
| Enterobacter cloacae | 0% | 1.68% | 4.79% | 0% |
| Enterobacter hormaechei | 0.36% | 2.57% | 5.09% | 0% |
| Enterobacter kobei | 0% | 1.38% | 3.06% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 0.72% | 0% |
| Escherichia albertii | 0% | 0.56% | 1.94% | 0% |
| Escherichia coli | 1.26% | 1.84% | 4.84% | 0% |
| Escherichia fergusonii | 0% | 0.71% | 5.43% | 0% |
| Glaesserella parasuis | 3.85% | 0% | 0.51% | 0% |
| Klebsiella aerogenes | 2% | 5.43% | 3.11% | 0% |
| Klebsiella huaxiensis | 100% | 0% | 0% | 0% |
| Klebsiella michiganensis | 6.45% | 9.14% | 5.05% | 0% |
| Klebsiella oxytoca | 0% | 0% | 2.94% | 0% |
| Klebsiella pneumoniae | 2.49% | 2.52% | 5.96% | 0% |
| Klebsiella quasipneumoniae | 0% | 2.33% | 10.79% | 0% |
| Leclercia adecarboxylata | 0% | 0% | 6.98% | 0% |
| Morganella morganii | 9.62% | 0% | 7.98% | 0% |
| Proteus mirabilis | 13.76% | 5% | 5.78% | 0% |
| Proteus vulgaris | 0% | 11.11% | 5.56% | 0% |
| Providencia rettgeri | 2.94% | 0% | 1.27% | 0% |
| Providencia stuartii | 0% | 0% | 2.27% | 0% |
| Pseudomonas aeruginosa | 1.69% | 0.88% | 0.17% | 0% |
| Pseudomonas putida | 1.41% | 4% | 0% | 0% |
| Raoultella planticola | 0% | 9.3% | 7.69% | 0% |
| Salmonella enterica | 1.2% | 3.77% | 1.42% | 0% |
| Serratia marcescens | 3.03% | 0.65% | 5.24% | 0% |
| Shigella boydii | 0% | 0% | 6.67% | 0% |
| Shigella flexneri | 1% | 5.62% | 3.57% | 0% |
| Shigella sonnei | 2.44% | 0% | 2.78% | 0% |
| Stenotrophomonas maltophilia | 0% | 0% | 0.15% | 0% |
| Vibrio cholerae | 0% | 5.26% | 0.13% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 570