tobramycin [Antibiotic]

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Accession ARO:0000052
Synonym(s)Tobrex Tobramitsetin Tobramaxin Tobracin Gotabiotic Tobradistin Nebcin Tobramycetin Tobramicin Tenebrimycin
DefinitionTobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.
Drug Classaminoglycoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
32 ontology terms | Show
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
+ AAC(6')-Im confers_resistance_to_antibiotic
+ AAC(6') [AMR Gene Family] confers_resistance_to_antibiotic
+ APH(2'') [AMR Gene Family] confers_resistance_to_antibiotic
+ ANT(2'')-Ia confers_resistance_to_antibiotic
+ armA confers_resistance_to_antibiotic
+ rmtA confers_resistance_to_antibiotic
+ rmtB confers_resistance_to_antibiotic
+ rmtC confers_resistance_to_antibiotic
+ sgm confers_resistance_to_antibiotic
+ ANT(4') [AMR Gene Family] confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tobramycin confers_resistance_to_antibiotic
+ Mycobacteroides abscessus 16S rRNA mutation conferring resistance to tobramycin confers_resistance_to_antibiotic
+ Mycobacteroides chelonae 16S rRNA mutation conferring resistance to tobramycin confers_resistance_to_antibiotic
+ AAC(6')-Ib confers_resistance_to_antibiotic
+ AAC(6')-Ib' confers_resistance_to_antibiotic
+ AAC(3)-Ib/AAC(6')-Ib'' confers_resistance_to_antibiotic
+ AAC(2')-Ia confers_resistance_to_antibiotic
+ AAC(2')-Ib confers_resistance_to_antibiotic
+ AAC(2')-Ic confers_resistance_to_antibiotic
+ AAC(2')-Id confers_resistance_to_antibiotic
+ AAC(2')-Ie confers_resistance_to_antibiotic
+ MexXY-OprM confers_resistance_to_antibiotic
+ MexXY-OprA confers_resistance_to_antibiotic
+ AcrAD-TolC confers resistance to amikacin, gentamicin, and tobramycin confers_resistance_to_antibiotic
+ AAC(6')-Iag confers_resistance_to_antibiotic
+ aacA43 confers_resistance_to_antibiotic
+ AAC(3)-IIa confers_resistance_to_antibiotic
+ APH(2'')-If confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ AAC(3)-IVb confers_resistance_to_antibiotic

Kotra LP, et al. 2000. Antimicrob Agents Chemother 44(12): 3249-3256. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. (PMID 11083623)

Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)