tobramycin [Antibiotic]

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Accession ARO:0000052
Synonym(s)Gotabiotic Nebcin Tenebrimycin Tobracin Tobradistin Tobramaxin Tobramicin Tobramitsetin Tobramycetin Tobrex
DefinitionTobramycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Tobramycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.
SMILESN/A
PubChem36294
Drug Classaminoglycoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
116 ontology terms | Show
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
+ AAC(6')-Im confers_resistance_to_antibiotic
+ armA confers_resistance_to_antibiotic
+ rmtA confers_resistance_to_antibiotic
+ rmtB confers_resistance_to_antibiotic
+ rmtC confers_resistance_to_antibiotic
+ sgm confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tobramycin confers_resistance_to_antibiotic
+ Mycobacteroides abscessus 16S rRNA mutation conferring resistance to tobramycin confers_resistance_to_antibiotic
+ Mycobacteroides chelonae 16S rRNA mutation conferring resistance to tobramycin confers_resistance_to_antibiotic
+ AAC(6')-Ib' confers_resistance_to_antibiotic
+ MexXY-OprM confers_resistance_to_antibiotic
+ MexXY-OprA confers_resistance_to_antibiotic
+ AAC(6')-I-43 confers_resistance_to_antibiotic
+ APH(2'')-If confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ AAC(3)-IVb confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr3 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr4 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr5 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr6 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr7 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr8 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr9 confers_resistance_to_antibiotic
+ AAC(6')-Ib11 confers_resistance_to_antibiotic
+ AAC(6')-Ib3 confers_resistance_to_antibiotic
+ AAC(6')-29b confers_resistance_to_antibiotic
+ AAC(6')-29a confers_resistance_to_antibiotic
+ AAC(6')-31 confers_resistance_to_antibiotic
+ AAC(6')-32 confers_resistance_to_antibiotic
+ PvrR confers_resistance_to_antibiotic
+ rmtD confers_resistance_to_antibiotic
+ rmtD2 confers_resistance_to_antibiotic
+ rmtG confers_resistance_to_antibiotic
+ rmtH confers_resistance_to_antibiotic
+ APH(2'')-IIIa confers_resistance_to_antibiotic
+ APH(2'')-IVa confers_resistance_to_antibiotic
+ APH(2'')-Ig confers_resistance_to_antibiotic
+ APH(2'')-Ie confers_resistance_to_antibiotic
+ AAC(3)-IIg confers_resistance_to_antibiotic
+ AAC(3)-IId confers_resistance_to_antibiotic
+ AAC(3)-IIe confers_resistance_to_antibiotic
+ AAC(3)-IIc confers_resistance_to_antibiotic
+ AAC(3)-IIb confers_resistance_to_antibiotic
+ AAC(3)-IIa confers_resistance_to_antibiotic
+ AAC(3)-IIIa confers_resistance_to_antibiotic
+ AAC(3)-IIIb confers_resistance_to_antibiotic
+ AAC(3)-IVa confers_resistance_to_antibiotic
+ AAC(2')-Ia confers_resistance_to_antibiotic
+ AAC(2')-Ib confers_resistance_to_antibiotic
+ AAC(2')-Ic confers_resistance_to_antibiotic
+ AAC(2')-Id confers_resistance_to_antibiotic
+ AAC(2')-Ie confers_resistance_to_antibiotic
+ AAC(6')-If confers_resistance_to_antibiotic
+ AAC(6')-Ig confers_resistance_to_antibiotic
+ AAC(6')-Ih confers_resistance_to_antibiotic
+ AAC(6')-Ii confers_resistance_to_antibiotic
+ AAC(6')-Ij confers_resistance_to_antibiotic
+ AAC(6')-Ik confers_resistance_to_antibiotic
+ AAC(6')-Ip confers_resistance_to_antibiotic
+ AAC(6')-Iq confers_resistance_to_antibiotic
+ AAC(6')-Ir confers_resistance_to_antibiotic
+ AAC(6')-Is confers_resistance_to_antibiotic
+ AAC(6')-Isa confers_resistance_to_antibiotic
+ AAC(6')-It confers_resistance_to_antibiotic
+ AAC(6')-Iu confers_resistance_to_antibiotic
+ AAC(6')-Iv confers_resistance_to_antibiotic
+ AAC(6')-Iw confers_resistance_to_antibiotic
+ AAC(6')-Ix confers_resistance_to_antibiotic
+ AAC(6')-Iy confers_resistance_to_antibiotic
+ AAC(6')-Iz confers_resistance_to_antibiotic
+ AAC(6')-Iaa confers_resistance_to_antibiotic
+ AAC(6')-Iad confers_resistance_to_antibiotic
+ AAC(6')-Iae confers_resistance_to_antibiotic
+ AAC(6')-Iaf confers_resistance_to_antibiotic
+ AAC(6')-Iai confers_resistance_to_antibiotic
+ AAC(6')-Ia confers_resistance_to_antibiotic
+ AAC(6')-Ic confers_resistance_to_antibiotic
+ AAC(6')-Iak confers_resistance_to_antibiotic
+ AAC(6')-Ian confers_resistance_to_antibiotic
+ AAC(6')-Iaj confers_resistance_to_antibiotic
+ AAC(6')-Il confers_resistance_to_antibiotic
+ AAC(6')-I-48 confers_resistance_to_antibiotic
+ AAC(6')-Iap confers_resistance_to_antibiotic
+ AAC(6')-Ib4 confers_resistance_to_antibiotic
+ AAC(6')-Ib7 confers_resistance_to_antibiotic
+ AAC(6')-Ib8 confers_resistance_to_antibiotic
+ AAC(6')-Ib9 confers_resistance_to_antibiotic
+ AAC(6')-Ib10 confers_resistance_to_antibiotic
+ AAC(6')-Ib-Suzhou confers_resistance_to_antibiotic
+ AAC(6')-Ib-Hangzhou confers_resistance_to_antibiotic
+ AAC(6')-Ib-SK confers_resistance_to_antibiotic
+ AAC(6')-Ib confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr1 confers_resistance_to_antibiotic
+ AAC(6')-IIa confers_resistance_to_antibiotic
+ AAC(6')-IIb confers_resistance_to_antibiotic
+ AAC(6')-IIc confers_resistance_to_antibiotic
+ ANT(4')-Ia confers_resistance_to_antibiotic
+ ANT(4')-Ib confers_resistance_to_antibiotic
+ ANT(4')-IIa confers_resistance_to_antibiotic
+ ANT(4')-IIb confers_resistance_to_antibiotic
+ ANT(2'')-Ia confers_resistance_to_antibiotic
+ AAC(6')-Iid confers_resistance_to_antibiotic
+ AAC(6')-Iih confers_resistance_to_antibiotic
+ AAC(3)-Ib/AAC(6')-Ib3 bifunctional protein confers_resistance_to_antibiotic
+ AAC(6')-Ie-APH(2'')-Ia bifunctional protein confers_resistance_to_antibiotic
+ ANT(3'')-II-AAC(6')-IId bifunctional protein confers_resistance_to_antibiotic
+ AAC(6')-I30 confers_resistance_to_antibiotic
+ AAC(6')-I33 confers_resistance_to_antibiotic
+ dfrL confers_resistance_to_antibiotic
+ AcrAD-TolC confers_resistance_to_antibiotic
+ acrD confers_resistance_to_antibiotic
+ CrcB confers_resistance_to_antibiotic
+ AmrAB-OprM confers_resistance_to_antibiotic
+ aac(6')-Ib-cr10 confers_resistance_to_antibiotic
+ aac(6')-Ib-cr11 confers_resistance_to_antibiotic
Publications

Kotra LP, et al. 2000. Antimicrob Agents Chemother 44(12): 3249-3256. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. (PMID 11083623)

Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)
Curator Acknowledgements
Curator Description Most Recent Edit